The tuberculosis spectrum: Translating basic research into pediatric clinical practice.
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
18
05
2015
revised:
21
10
2015
accepted:
25
10
2015
pubmed:
9
11
2015
medline:
15
5
2021
entrez:
9
11
2015
Statut:
ppublish
Résumé
Recent studies suggest that the classical dichotomous classification of "active" and "latent" tuberculosis (TB) is no longer acceptable since "TB infection" encompasses a wide spectrum of conditions ranging from asymptomatic to lethal disease. In an attempt to address these issues from a pediatric clinical perspective, we describe two children with microbiologically confirmed TB but lacking any clinical and radiological evidence of disease. These two cases highlight the hypothesis that TB cannot be divided in two simple categories, but it covers a wide spectrum of manifestations ranging from asymptomatic to lethal TB. The implications of these results in the context of the new TB spectrum and the related clinical issues are discussed.
Identifiants
pubmed: 26547272
pii: S0306-9877(15)00410-7
doi: 10.1016/j.mehy.2015.10.028
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108091Informations de copyright
Copyright © 2015 Elsevier Ltd. All rights reserved.