[Red yeast-rice-induced muscular injuries: Analysis of French pharmacovigilance database and literature review].
Atteintes musculaires et levure de riz rouge : analyse des données de la base nationale de pharmacovigilance et revue de la littérature.
Atteintes musculaires
Levure de riz rouge
Muscular injuries
Phytotherapy
Phytothérapie
Red yeast rice
Statin
Statine
Journal
Therapie
ISSN: 1958-5578
Titre abrégé: Therapie
Pays: France
ID NLM: 0420544
Informations de publication
Date de publication:
Historique:
received:
02
10
2014
accepted:
08
06
2015
medline:
10
3
2017
pubmed:
10
3
2017
entrez:
10
3
2017
Statut:
ppublish
Résumé
Red yeast rice (RYR) is a dietary supplement containing monacolins obtained by fermentation of Monascus purpureus strains. Because of its structural homology with lovastatin, monacolin K inhibits HMG-CoA reductase and shows hypocholesterolemic properties comparable to synthetic statins. We studied all cases of myopathy involving RYR reported in the French national pharmacovigilance database (6 cases) and in scientific literature (9 cases). Among these cases, 9 showed elevated creatine kinase, 3 rhabdomyolysis and 2 myalgia. Recent studies seem to show good efficacy of the RYR, however, our work reports the existence of related muscular disorders. In addition, dietary supplements currently available on the market may show considerable variability of formulation and/or the presence of contaminants. When clinicobiological disorders occur, physicians should consider the eventual use of an herbal treatment.
Identifiants
pubmed: 28277227
pii: S0040-5957(16)30054-3
doi: 10.2515/therapie/2015053
pii:
doi:
Types de publication
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
S31-S40Informations de copyright
Copyright © 2014 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.