Prenatal stress and epigenetics.

Animals DNA Methylation Epigenesis, Genetic Epigenomics Female Humans Phenotype Pregnancy Prenatal Exposure Delayed Effects / genetics
DNA methylation DOHaD Epigenetics Prenatal stress

Journal

Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090

Informations de publication

Date de publication:
10 2020
Historique:
received: 16 11 2016
revised: 15 05 2017
accepted: 16 05 2017
pubmed: 23 5 2017
medline: 22 6 2021
entrez: 23 5 2017
Statut: ppublish

Résumé

In utero exposure to environmental stress in both animals and humans could result in long-term epigenome alterations which further lead to consequences for adaptation and development in the offspring. Epigenetics, especially DNA methylation, is considered one of the most widely studied and well-characterized mechanisms involved in the long-lasting effects of in utero stress exposure. In this review, we outlined evidence from animal and human prenatal research supporting the view that prenatal stress could lead to lasting, broad and functionally organized signatures in DNA methylation which, in turn, could mediate exposure-phenotype associations. We also emphasized the advantage of using stressor from quasi-randomly assigned experiments. Furthermore, we discuss challenges that still need to be addressed in this field in the future.

Identifiants

DOI: 10.1016/j.neubiorev.2017.05.016 PMID: 28528960
pubmed: 28528960
pii: S0149-7634(16)30726-6
doi: 10.1016/j.neubiorev.2017.05.016
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

198-210

Subventions

Organisme : CIHR
ID : MOP-1150067
Pays : Canada

Informations de copyright

Copyright © 2017 Elsevier Ltd. All rights reserved.

Auteurs

L Cao-Lei (L)

Department of Psychiatry, McGill University and Psychosocial Research Division, Douglas Hospital Research Centre, Canada. Electronic address: Lei.cao@mail.mcgill.ca.

S R de Rooij (SR)

Department of Clinical Epidemiology, Biostatistics and Bio Informatics, Academic Medical Centre, University of Amsterdam, Netherlands. Electronic address: s.r.derooij@amc.uva.nl.

S King (S)

Department of Psychiatry, McGill University and Psychosocial Research Division, Douglas Hospital Research Centre, Canada. Electronic address: Suzanne.king@mcgill.ca.

S G Matthews (SG)

Department of Physiology, Faculty of Medicine, University of Toronto, Canada. Electronic address: Stephen.Matthews@utoronto.ca.

G A S Metz (GAS)

Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Canada. Electronic address: gerlinde.metz@uleth.ca.

T J Roseboom (TJ)

Departments of Clinical Epidemiology, Biostatistics and Bio Informatics and Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Netherlands. Electronic address: t.j.roseboom@amc.uva.nl.

M Szyf (M)

Department of Pharmacology and Therapeutics and Sackler Program for Epigenetics and Developmental Psychobiology, McGill University, Canada. Electronic address: moshe.szyf@mcgill.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Prenatal stress and epigenetics.
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Prenatal stress and epigenetics.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Prenatal stress and epigenetics.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Prenatal stress and epigenetics.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prenatal stress and epigenetics.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Prenatal stress and epigenetics.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Prenatal stress and epigenetics.
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Prenatal stress and epigenetics.