Prognostic factors in head and neck melanoma according to facial aesthetic units.
Adolescent
Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
Head and Neck Neoplasms
/ pathology
Humans
Kaplan-Meier Estimate
Male
Melanoma
/ pathology
Middle Aged
Neoplasm Recurrence, Local
Predictive Value of Tests
Prognosis
Retrospective Studies
Scalp
/ pathology
Skin Neoplasms
/ pathology
Young Adult
Journal
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
ISSN: 1827-1820
Titre abrégé: G Ital Dermatol Venereol
Pays: Italy
ID NLM: 8102852
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
pubmed:
28
7
2017
medline:
15
12
2020
entrez:
28
7
2017
Statut:
ppublish
Résumé
Head and neck melanoma is a clinical challenge. Indeed, cutaneous head and neck melanoma shows a worse prognosis in comparison to melanomas of other body sites. Although the emphasis on facial cosmetic preservation plays a pivotal role in comparison to other body areas, specific Facial Aesthetic Units (FAU) could also play a key role in the prognostic evaluation of the malignancy. The aim of the current study was to evaluate the general outcome and clinicopathological features of head and neck melanoma and to detect prognostic differences according to each FAU. The Kaplan-Meier product was used to calculate survival curves, while Cox proportional-hazard regression was performed to evaluate the predictive value of each FAU. A total of 221 head and neck melanoma patients was included in our analysis. In the nasal FAU, we found a high rate of local recurrence, which affected significantly disease-free survival. The worse prognosis was observed in melanoma of the scalp, which showed a greater tendency to skip metastases in internal organs. Moreover, we found that scalp showed a low incidence of non-melanoma skin cancers, if compared to other FAU, highlighting that the scalp local milieu might play a more prominent role in melanoma biology than chronic UV exposition. Although FAUs have an aesthetic function, they could also play a role in the evaluation and follow-up of melanoma.
Sections du résumé
BACKGROUND
BACKGROUND
Head and neck melanoma is a clinical challenge. Indeed, cutaneous head and neck melanoma shows a worse prognosis in comparison to melanomas of other body sites. Although the emphasis on facial cosmetic preservation plays a pivotal role in comparison to other body areas, specific Facial Aesthetic Units (FAU) could also play a key role in the prognostic evaluation of the malignancy.
METHODS
METHODS
The aim of the current study was to evaluate the general outcome and clinicopathological features of head and neck melanoma and to detect prognostic differences according to each FAU. The Kaplan-Meier product was used to calculate survival curves, while Cox proportional-hazard regression was performed to evaluate the predictive value of each FAU.
RESULTS
RESULTS
A total of 221 head and neck melanoma patients was included in our analysis. In the nasal FAU, we found a high rate of local recurrence, which affected significantly disease-free survival. The worse prognosis was observed in melanoma of the scalp, which showed a greater tendency to skip metastases in internal organs. Moreover, we found that scalp showed a low incidence of non-melanoma skin cancers, if compared to other FAU, highlighting that the scalp local milieu might play a more prominent role in melanoma biology than chronic UV exposition.
CONCLUSIONS
CONCLUSIONS
Although FAUs have an aesthetic function, they could also play a role in the evaluation and follow-up of melanoma.
Identifiants
pubmed: 28748684
pii: S0392-0488.17.05685-1
doi: 10.23736/S0392-0488.17.05685-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM