Blood cell count in antipsychotic-naive patients with non-affective psychosis.
WBC count
drug naïve
metabolic disturbances
metabolic syndrome
monocyte count
neutrophil count
non-affective psychosis
schizophrenia
Journal
Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
17
10
2016
revised:
20
02
2017
accepted:
25
04
2017
pubmed:
9
8
2017
medline:
23
7
2019
entrez:
9
8
2017
Statut:
ppublish
Résumé
Schizophrenia is a complex medical entity with a reduced life expectancy, mostly due to an increased prevalence of cardiovascular diseases compared to the general population. An unbalanced immune response and a pro-inflammatory state might underlie this process. In treated patients, abnormal white blood cell (WBC), lymphocyte and neutrophil count suggests atypical immune response related to clinical variables. We aimed to test the hypothesis that newly diagnosed naïve patients with non-affective psychosis would show abnormal blood cell count values after controlling for potential confounding factors compared to matched controls. Seventy-five patients were compared with 80 controls matched for age, gender, body mass index and smoking. Analyses were conducted before and after controlling for smoking. Patients and controls displayed similar mean values (×10 These results suggest that abnormal immune response is present before the effects of medication and other confounders had taken place. Increased immune parameters might underlie the high ratio of medical co-morbidities described in schizophrenia.
Sections du résumé
BACKGROUND
Schizophrenia is a complex medical entity with a reduced life expectancy, mostly due to an increased prevalence of cardiovascular diseases compared to the general population. An unbalanced immune response and a pro-inflammatory state might underlie this process. In treated patients, abnormal white blood cell (WBC), lymphocyte and neutrophil count suggests atypical immune response related to clinical variables. We aimed to test the hypothesis that newly diagnosed naïve patients with non-affective psychosis would show abnormal blood cell count values after controlling for potential confounding factors compared to matched controls.
METHODS
Seventy-five patients were compared with 80 controls matched for age, gender, body mass index and smoking. Analyses were conducted before and after controlling for smoking.
RESULTS
Patients and controls displayed similar mean values (×10
CONCLUSIONS
These results suggest that abnormal immune response is present before the effects of medication and other confounders had taken place. Increased immune parameters might underlie the high ratio of medical co-morbidities described in schizophrenia.
Substances chimiques
Antipsychotic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-100Subventions
Organisme : NIDDK NIH HHS
ID : RO1 DK069265
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK069265
Pays : United States
Informations de copyright
© 2017 John Wiley & Sons Australia, Ltd.