Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence.

Cardiovascular Diseases / prevention & control Humans Lycopene / chemistry Solanum lycopersicum / chemistry
cardiovascular disease lycopene meta-analysis mortality systematic review tomato

Journal

Critical reviews in food science and nutrition
ISSN: 1549-7852
Titre abrégé: Crit Rev Food Sci Nutr
Pays: United States
ID NLM: 8914818

Informations de publication

Date de publication:
2019
Historique:
pubmed: 12 8 2017
medline: 14 6 2019
entrez: 12 8 2017
Statut: ppublish

Résumé

Worldwide, cardiovascular diseases (CVDs) remains as the main cause of mortality. Observational studies supports an association between intake of tomato products or lycopene with a reduced CVDs risk. Our aim was to undertake a systematic review and meta-analysis of the evidence on the topic. Medline, Web of Science, and Scopus were searched from inception until July 2017. We included longitudinal and cross-sectional studies reporting associations between lycopene and tomato consumption and cardiovascular morbidity and mortality among adult subjects. Random-effects models were used to determine the pooled effect sizes. Twenty-eight publications met our inclusion criteria and 25 studies provided quantitative data for meta-analysis. Results showed that individuals in the highest consumption category of, or with the highest serum concentration of, lycopene had significantly lower risk of stroke (hazard ratio (HR) 0.74, 0.62-0.89, p = 0.02; I This comprehensive meta-analysis suggests that high-intakes or high-serum concentration of lycopene are associated with significant reductions in the risk of stroke (26%), mortality (37%) and CVDs (14%).

Sections du résumé

BACKGROUND AND AIMS OBJECTIVE
Worldwide, cardiovascular diseases (CVDs) remains as the main cause of mortality. Observational studies supports an association between intake of tomato products or lycopene with a reduced CVDs risk. Our aim was to undertake a systematic review and meta-analysis of the evidence on the topic.
METHODS METHODS
Medline, Web of Science, and Scopus were searched from inception until July 2017. We included longitudinal and cross-sectional studies reporting associations between lycopene and tomato consumption and cardiovascular morbidity and mortality among adult subjects. Random-effects models were used to determine the pooled effect sizes.
RESULTS RESULTS
Twenty-eight publications met our inclusion criteria and 25 studies provided quantitative data for meta-analysis. Results showed that individuals in the highest consumption category of, or with the highest serum concentration of, lycopene had significantly lower risk of stroke (hazard ratio (HR) 0.74, 0.62-0.89, p = 0.02; I
CONCLUSIONS CONCLUSIONS
This comprehensive meta-analysis suggests that high-intakes or high-serum concentration of lycopene are associated with significant reductions in the risk of stroke (26%), mortality (37%) and CVDs (14%).

Identifiants

DOI: 10.1080/10408398.2017.1362630 PMID: 28799780
pubmed: 28799780
doi: 10.1080/10408398.2017.1362630
doi:

Substances chimiques

Lycopene SB0N2N0WV6

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

141-158

Auteurs

Ho M Cheng (HM)

a Department of Applied Sciences, Faculty of Health and Life Sciences , Northumbria University , Newcastle upon Tyne , UK.

Georgios Koutsidis (G)

a Department of Applied Sciences, Faculty of Health and Life Sciences , Northumbria University , Newcastle upon Tyne , UK.

John K Lodge (JK)

a Department of Applied Sciences, Faculty of Health and Life Sciences , Northumbria University , Newcastle upon Tyne , UK.

Ammar W Ashor (AW)

b Human Nutrition Research Centre, Institute of Cellular Medicine and Newcastle University Institute for Ageing , Newcastle University , Newcastle upon Tyne , UK.

Mario Siervo (M)

b Human Nutrition Research Centre, Institute of Cellular Medicine and Newcastle University Institute for Ageing , Newcastle University , Newcastle upon Tyne , UK.
ORCID: 0000-0001-5515-0944

Jose Lara (J)

a Department of Applied Sciences, Faculty of Health and Life Sciences , Northumbria University , Newcastle upon Tyne , UK.
ORCID: 0000-0002-4449-9304

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Lycopene and tomato and risk of cardiovascular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lycopene and tomato and risk of cardiovascular...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Caroténoïdes › Lycopène › Lycopene and tomato and risk of cardiovascular...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Solanales › Solanaceae › Lycopersicon esculentum › Lycopene and tomato and risk of cardiovascular...