Efficacy and Safety of the Early Addition of Vasopressin to Norepinephrine in Septic Shock.
Adult
Aged
Arterial Pressure
/ drug effects
Drug Administration Schedule
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Norepinephrine
/ administration & dosage
Organ Dysfunction Scores
Retrospective Studies
Shock, Septic
/ drug therapy
Time Factors
Treatment Outcome
Vasoconstrictor Agents
/ administration & dosage
Vasopressins
/ administration & dosage
mean arterial pressure
norepinephrine
septic shock
vasopressin
Journal
Journal of intensive care medicine
ISSN: 1525-1489
Titre abrégé: J Intensive Care Med
Pays: United States
ID NLM: 8610344
Informations de publication
Date de publication:
Historique:
pubmed:
19
8
2017
medline:
12
9
2020
entrez:
19
8
2017
Statut:
ppublish
Résumé
Delays in achievement of target mean arterial pressure (MAP) have been associated with increased mortality in patients with septic shock. Vasopressin may be added to norepinephrine to raise MAP or decrease norepinephrine dosage. The purpose of this study was to determine whether early initiation of vasopressin to norepinephrine resulted in a reduced time to target MAP compared to norepinephrine monotherapy. This retrospective cohort study compared early addition of vasopressin within 4 hours of septic shock onset to norepinephrine versus initial norepinephrine monotherapy in medically, critically ill patients with septic shock admitted from May 2014 to October 2015. Time to goal MAP was compared using Student Each group contained 48 patients. Mean arterial pressure (61.5 vs 58.6 mm Hg) and intravenous fluid volume received at vasopressor initiation (14.3 vs 25.2 hours, Early initiation of vasopressin in patients with septic shock may achieve and maintain goal MAP sooner and resolve organ dysfunction at 72 hours more effectively than later or no initiation.
Sections du résumé
BACKGROUND
BACKGROUND
Delays in achievement of target mean arterial pressure (MAP) have been associated with increased mortality in patients with septic shock. Vasopressin may be added to norepinephrine to raise MAP or decrease norepinephrine dosage. The purpose of this study was to determine whether early initiation of vasopressin to norepinephrine resulted in a reduced time to target MAP compared to norepinephrine monotherapy.
METHODS
METHODS
This retrospective cohort study compared early addition of vasopressin within 4 hours of septic shock onset to norepinephrine versus initial norepinephrine monotherapy in medically, critically ill patients with septic shock admitted from May 2014 to October 2015. Time to goal MAP was compared using Student
RESULTS
RESULTS
Each group contained 48 patients. Mean arterial pressure (61.5 vs 58.6 mm Hg) and intravenous fluid volume received at vasopressor initiation (14.3 vs 25.2 hours,
CONCLUSION
CONCLUSIONS
Early initiation of vasopressin in patients with septic shock may achieve and maintain goal MAP sooner and resolve organ dysfunction at 72 hours more effectively than later or no initiation.
Identifiants
pubmed: 28820036
doi: 10.1177/0885066617725255
doi:
Substances chimiques
Vasoconstrictor Agents
0
Vasopressins
11000-17-2
Norepinephrine
X4W3ENH1CV
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM