SIMULTANEOUS CHOROIDAL AND RETINAL METASTASES FROM LUNG CARCINOMA.
Adenocarcinoma, Mucinous
/ diagnosis
Choroid
/ pathology
Choroid Neoplasms
/ diagnosis
Female
Fluorescein Angiography
/ methods
Fundus Oculi
Humans
Lung Neoplasms
/ pathology
Middle Aged
Neoplasm Metastasis
Ophthalmoscopy
Retina
/ pathology
Retinal Neoplasms
/ diagnosis
Tomography, Optical Coherence
/ methods
Journal
Retinal cases & brief reports
ISSN: 1937-1578
Titre abrégé: Retin Cases Brief Rep
Pays: United States
ID NLM: 101298744
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
30
8
2017
medline:
21
8
2020
entrez:
30
8
2017
Statut:
ppublish
Résumé
Intraocular metastasis is most commonly found within the choroid because of its luxurious blood supply, whereas metastasis to the retina, from a separate blood supply, is very rare. We report a rare case of synchronous metastases from lung carcinoma to the choroid of the right eye and the retina of the left eye and a complaint of low vision in the right eye. We report a 63-year-old woman with progressive reduction of vision in her right eye for 1 year without previous history of cancer. The patient underwent comprehensive ophthalmic examination that included a multimodal evaluation: near-infrared reflectance scanning laser ophthalmoscopy, blue autofluorescence, and enhanced-depth imaging spectral domain optical coherence tomography (EDI SD-OCT; Heidelberg Engineering, Heidelberg, Germany). Ophthalmoscopic examination revealed a yellow choroidal mass measuring 6 × 6 mm with overlying subretinal fluid and involving the macular area in the right eye. In the left eye, there was a superior juxtapapillary yellow-colored mass involving the retina and measuring 1 × 1 mm. Optical coherence tomography revealed the subretinal fluid contouring a dome-shaped choroidal mass in the right eye and intraretinal nodular tumor superior to the optic disk of the left eye. Chest computed tomography revealed a pulmonary nodule measuring 2.5 mm × 1.4 mm, and biopsy of the liver metastasis confirmed the diagnosis of mucinous lung carcinoma. The final diagnosis was presumed choroidal metastasis in the right eye and retinal metastasis in the left eye from underlying mucinous carcinoma of the lung.
Sections du résumé
BACKGROUND
BACKGROUND
Intraocular metastasis is most commonly found within the choroid because of its luxurious blood supply, whereas metastasis to the retina, from a separate blood supply, is very rare. We report a rare case of synchronous metastases from lung carcinoma to the choroid of the right eye and the retina of the left eye and a complaint of low vision in the right eye.
METHODS
METHODS
We report a 63-year-old woman with progressive reduction of vision in her right eye for 1 year without previous history of cancer. The patient underwent comprehensive ophthalmic examination that included a multimodal evaluation: near-infrared reflectance scanning laser ophthalmoscopy, blue autofluorescence, and enhanced-depth imaging spectral domain optical coherence tomography (EDI SD-OCT; Heidelberg Engineering, Heidelberg, Germany).
RESULTS
RESULTS
Ophthalmoscopic examination revealed a yellow choroidal mass measuring 6 × 6 mm with overlying subretinal fluid and involving the macular area in the right eye. In the left eye, there was a superior juxtapapillary yellow-colored mass involving the retina and measuring 1 × 1 mm. Optical coherence tomography revealed the subretinal fluid contouring a dome-shaped choroidal mass in the right eye and intraretinal nodular tumor superior to the optic disk of the left eye. Chest computed tomography revealed a pulmonary nodule measuring 2.5 mm × 1.4 mm, and biopsy of the liver metastasis confirmed the diagnosis of mucinous lung carcinoma.
CONCLUSION
CONCLUSIONS
The final diagnosis was presumed choroidal metastasis in the right eye and retinal metastasis in the left eye from underlying mucinous carcinoma of the lung.
Identifiants
pubmed: 28850049
doi: 10.1097/ICB.0000000000000629
pii: 01271216-202001410-00022
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-95Références
Cury Junior CE, Cury Júnior A, Siqueira RC, Storti C. Choroidal metastasis simulating uveal effusion syndrome: case report [in Portuguese]. Arq Bras Oftalmol 2008;71:291–294.
Shields JA, Shields CL. Intraocular tumors. In: An Atlas and Textbook. 3rd ed. Philadelphia, PA: Lippincott Wolters Kluwers; 2016:213–245.
Arisawa M. Ueber echtes Carcinom der retina [in German]. Klin Monatsbl Augenh 1914;32:386.
Smoleroff JS, Agatson SA. Meta static carcinoma of the retina: report of a case with pathological observations. Arch Ophthalmol 1934;1:359.
Uhler EM. Metastatic malignant melanoma of the retina. Am J Ophthalmol 1940;23:158–162.
Kennedy RJ, Rummel WD, McArthy JL, Hazard JB. Metastatic carcinoma of the retina. AMA Arch Ophth 1958;60:12.
Liddicoat DA, Wolter JR, Wilkinson WC. Retinal metastasis of malignant melanomablastoma. Am J Ophthalmol 1959;48:172–177.
Riffenburgh RS. Metastatic malignant melanoma to the retina. Arch Ophthalmol 1961;66:487–489.
Flindall RJ, Fleming KO. Metastatic tumour of the retina. Can J Ophthalmol 1967;2:130.
Young SE, Cruciger M, Lukeman J. Metastatic carcinoma to the retina: case report. Ophthalmology 1979;86:1350–1354.
Anthony AC, Hepler RS, Foos RY. Isolated metastasis to the optic nerve. Surv Ophthalmol 1981;26:75–83.
Muci-Mendoza R, Arevalo JF, Ramella M, Fuenmayor-Rivera D. Optic nerve metastasis from oat cell lung adenocarcinoma: regression after radiotherapy. Ophthalmic Surg Lasers 2001;32:349–351.
Letson AD, Davidorf FH. Bilateral retinal metastases from cutaneous malignant melanoma. Arch Ophthalmol 1982;100:605–607.
Leys AM, Van Eyck LM, Nuttin BJ, et al. Metastatic carcinoma to the retina clinicopathologic findings in two cases. Arch Ophthalmol 1990;108:1448–1452.
Spraul CW, Lang GE, Grossnikiaus HE, Lang GK. Metastatic adenocarcinoma to the retina in a patient with muir-torre syndrome. Am J Ophthalmol 1995;120:248–249.
Saornil MA, Blanco G, Sarasa JL, et al. Isolated metastasis of gastric adenocarcinoma to the retina: first presentation of systemic disease. Acta Ophthalmol Scand 2004;82:86–88.
Green WR. Retinal metastasis presenting as a retinal hemorrhage in a patient with adenocarcinoma of the cecum. Arch Ophthalmol 2005;123:850–853.
Alegret A, Cebulla CM, Dubovy SR, et al. Pediatric nasopharyngeal carcinoma with retinal metastasis. Retin Cases Brief Rep 2009;3:8–11.
Srivastava SK, Bergstrom C. Retinal metastasis. In: Ryan SJ, SriniVas SR, Hinton DR, Schachat AP, Wilkinson CP, Wiedemann P, eds. In Retina. 5th ed. St. Louis: Mosby; 2012:2185–2195.
Shields CL, McMahon JF, Atalay HT, et al. Retinal metastasis from systemic cancer in 8 cases. JAMA Ophthalmol 2014;132:1303–1308.
Gubbiotti M, Pistilli B, Tudini M, et al. Retinal metastasis regression with eribulin in a heavily pretreated breast cancer patient. Future Oncol 2015;11:17–22.
Nookala R, Batchu VV, Lee HM, et al. Difficult diagnosis of colon adenocarcinoma metastasis to retina: a case report and literature review. Int J Hematology Oncol Stem Cell Res 2016;10:186–190.
Shields CL, Shields JA, Gross NE, et al. Survey of 520 eyes with uveal metastases. Ophthalmology 1997;104:1265–1276.
Damato BE, Foulds WS. Tumour-associated retinal pigment epitheliopathy. Eye 1990;4:382–387.
Arevalo JF, Fernandez CF, Garcia RA. Optical coherence tomography characteristics of choroidal metastasis. Ophthalmology 2005;112:1612–1619.
Schaudig U, Hassenstein A, Bernd A, et al. Limitations of imaging choroidal tumors in vivo by optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 1998;236:588–592.
Obenauf CD, Shaw HE, Sydnor CF, Klintworh GK. Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol 1978;86:648–655.
Desai UR, Tawansy KA, Joondeph BC, Schiffman RM. Choroidal granulomas in systemic sarcoidosis. Retina 2001;21:40–47.
Shields JA, Shields CL. Clinical Features of Posterior Uveal Melanoma. Intraocular Tumors. An Atlas and Textbook. 3rd ed. Philadelphia, PA: Lippincott Wolters Kluwers; 2016:95–127.
Meyer I. Tumor metastático uveal: revisão de literatura sobre a neoplasia ocular maligna mais comum. Rev Bras Oftalmol 2011;70:51–56.
Coassin M, Ebrahimi KB, O'Brien JM, Stewart JM. Optical coherence tomography for retinal metastasis with unknown primary tumor. Ophthalmic Surg Lasers Imaging 2011;42:110–113.
Payne JF, Rahmam HT, Grossniklaus HE, Bergstrom CS. Retinal metastasis simulating cytomegalovirus retinitis. Ophthalmic Surg Lasers Imaging 2012;43:90–93.