Selective synaptic connections in the retinal pathway for night vision.
AII amacrine cell
RRID: AB_2079751
RRID: AB_2307351
RRID: AB_2315776
RRID: AB_2536190
retina
retinal ganglion cells
rod bipolar cell
scotopic vision
synapse
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
02
06
2017
revised:
15
08
2017
accepted:
16
08
2017
pubmed:
1
9
2017
medline:
17
4
2020
entrez:
1
9
2017
Statut:
ppublish
Résumé
The mammalian retina encodes visual information in dim light using rod photoreceptors and a specialized circuit: rods→rod bipolar cells→AII amacrine cell. The AII amacrine cell uses sign-conserving electrical synapses to modulate ON cone bipolar cell terminals and sign-inverting chemical (glycinergic) synapses to modulate OFF cone cell bipolar terminals; these ON and OFF cone bipolar terminals then drive the output neurons, retinal ganglion cells (RGCs), following light increments and decrements, respectively. The AII amacrine cell also makes direct glycinergic synapses with certain RGCs, but it is not well established how many types receive this direct AII input. Here, we investigated functional AII amacrine→RGC synaptic connections in the retina of the guinea pig (Cavia porcellus) by recording inhibitory currents from RGCs in the presence of ionotropic glutamate receptor (iGluR) antagonists. This condition isolates a specific pathway through the AII amacrine cell that does not require iGluRs: cone→ON cone bipolar cell→AII amacrine cell→RGC. These recordings show that AII amacrine cells make direct synapses with OFF Alpha, OFF Delta and a smaller OFF transient RGC type that co-stratifies with OFF Alpha cells. However, AII amacrine cells avoid making synapses with numerous RGC types that co-stratify with the connected RGCs. Selective AII connections ensure that a privileged minority of RGC types receives direct input from the night-vision pathway, independent from OFF bipolar cell activity. Furthermore, these results illustrate the specificity of retinal connections, which cannot be predicted solely by co-stratification of dendrites and axons within the inner plexiform layer.
Identifiants
pubmed: 28856684
doi: 10.1002/cne.24313
pmc: PMC5832573
mid: NIHMS919943
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-132Subventions
Organisme : NEI NIH HHS
ID : P30 EY026878
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY014454
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY007003
Pays : United States
Organisme : NEI NIH HHS
ID : F31 EY007003
Pays : United States
Informations de copyright
© 2017 Wiley Periodicals, Inc.
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