Connexins and pannexins in Alzheimer's disease.

Alzheimer Disease / metabolism Animals Connexins / metabolism Gap Junctions / metabolism Humans
Alzheimer’s Connexin Gap junctions Hemichannel Pannexin

Journal

Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130

Informations de publication

Date de publication:
16 03 2019
Historique:
received: 27 02 2017
revised: 14 08 2017
accepted: 01 09 2017
pubmed: 13 9 2017
medline: 7 9 2019
entrez: 13 9 2017
Statut: ppublish

Résumé

By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular tissues interact. In the normal brain, this interaction underlies homeostasis, metabolic supply and neuroprotection. In models of neuroinflammation these channels present aberrant functioning. Validation of the molecular mechanisms by which these membrane channels influence neurodegeneration particularly in Alzheimer's disease could lead to new and alternative therapeutic strategies targeting these channels.

Identifiants

DOI: 10.1016/j.neulet.2017.09.006 PMID: 28893592
pubmed: 28893592
pii: S0304-3940(17)30740-1
doi: 10.1016/j.neulet.2017.09.006
pii:
doi:

Substances chimiques

Connexins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100-105

Informations de copyright

Copyright © 2017 Elsevier B.V. All rights reserved.

Auteurs

Christian Giaume (C)

ICIRB, CNRS UMR7241/INSERM, 05, Collège de France, Paris Cedex 05, France.

Juan C Sáez (JC)

Departamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago, and Instituto Milenio de Neurociencias de Valparaíso, Chile.

Weihong Song (W)

Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada.

Luc Leybaert (L)

Physiology group, Department of Basic Medical Sciences, Ghent University, Ghent, Belgium.

Christian C Naus (CC)

Department of Cellular & Physiological Sciences, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada. Electronic address: christian.naus@ubc.ca.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Connexins and pannexins in Alzheimer's disease.
questionsmedicales.fr › Eucaryotes › Animaux › Connexins and pannexins in Alzheimer's disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Connexines › Connexins and pannexins in Alzheimer's disease.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Jonctions communicantes › Connexins and pannexins in Alzheimer's disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Connexins and pannexins in Alzheimer's disease.