The 9p21 Rs 1333040 polymorphism is associated with coronary microvascular obstruction in ST-segment elevation myocardial infarction treated by primary angioplasty.
Acute Coronary Syndrome
/ metabolism
Aged
Angioplasty
/ methods
Chromosomes, Human, Pair 9
/ genetics
Coronary Angiography
/ methods
Coronary Occlusion
/ complications
Coronary Vessels
/ pathology
Cyclin-Dependent Kinase Inhibitor p21
/ genetics
Electrocardiography
/ methods
Female
Genetic Predisposition to Disease
Genotype
Humans
Incidence
Male
Microcirculation
/ genetics
Middle Aged
Myocardial Infarction
/ therapy
Neovascularization, Physiologic
/ genetics
Percutaneous Coronary Intervention
/ adverse effects
Polymorphism, Single Nucleotide
/ genetics
ST Elevation Myocardial Infarction
/ genetics
Thrombolytic Therapy
/ methods
9p21 polymorphism
Rs 1333040
ST-segment elevation myocardial infarction
acute coronary syndromes
microvascular obstruction
primary percutaneous coronary intervention
Journal
European heart journal. Acute cardiovascular care
ISSN: 2048-8734
Titre abrégé: Eur Heart J Acute Cardiovasc Care
Pays: England
ID NLM: 101591369
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
pubmed:
7
10
2017
medline:
21
4
2020
entrez:
7
10
2017
Statut:
ppublish
Résumé
Microvascular obstruction (MVO) after primary percutaneous coronary intervention (pPCI) leads to higher incidence of both early and late complications. A number of single nucleotide polymorphisms in 9p21 chromosome have been shown to affect angiogenesis in response to ischaemia. In particular, Rs1333040 with its three genotypic vriants C/C, T/C and T/T might influence the occurrence of MVO after pPCI. We enrolled ST-elevation myocardial infarction (STEMI) patients undergoing pPCI. The Rs1333040 polymorphism was evaluated by polymerase chain reaction-restriction fragment length polymorphism using restriction endonucleases (Bsml). Two expert operators unaware of the patients' identity performed the angiographic analysis; collaterals were assessed applying Rentrop's classification. Angiographic MVO was defined as a post-pPCI Thrombolysis In Myocardial Infarction (TIMI)<3 or TIMI 3 with myocardial blush grade 0 or 1, whereas electrocardiographic MVO was defined as ST segment resolution <70% one hour after pPCI. Among our 133 STEMI patients (mean age 63 ± 11 years, men 72%), 35 (26%) and 53 (40%) respectively experienced angiographic or electrocardiographic MVO. Angiographic and electrocardiographic MVO were different among the three variants ( Rs1333040 polymorphism genetic variants portend different MVO incidence. In particular, T/T genotype is related to angiographic and electrocardiographic MVO and to worse collaterals towards the culprit artery.
Sections du résumé
BACKGROUND
BACKGROUND
Microvascular obstruction (MVO) after primary percutaneous coronary intervention (pPCI) leads to higher incidence of both early and late complications. A number of single nucleotide polymorphisms in 9p21 chromosome have been shown to affect angiogenesis in response to ischaemia. In particular, Rs1333040 with its three genotypic vriants C/C, T/C and T/T might influence the occurrence of MVO after pPCI.
METHODS
METHODS
We enrolled ST-elevation myocardial infarction (STEMI) patients undergoing pPCI. The Rs1333040 polymorphism was evaluated by polymerase chain reaction-restriction fragment length polymorphism using restriction endonucleases (Bsml). Two expert operators unaware of the patients' identity performed the angiographic analysis; collaterals were assessed applying Rentrop's classification. Angiographic MVO was defined as a post-pPCI Thrombolysis In Myocardial Infarction (TIMI)<3 or TIMI 3 with myocardial blush grade 0 or 1, whereas electrocardiographic MVO was defined as ST segment resolution <70% one hour after pPCI.
RESULTS
RESULTS
Among our 133 STEMI patients (mean age 63 ± 11 years, men 72%), 35 (26%) and 53 (40%) respectively experienced angiographic or electrocardiographic MVO. Angiographic and electrocardiographic MVO were different among the three variants (
CONCLUSION
CONCLUSIONS
Rs1333040 polymorphism genetic variants portend different MVO incidence. In particular, T/T genotype is related to angiographic and electrocardiographic MVO and to worse collaterals towards the culprit artery.
Identifiants
pubmed: 28984467
doi: 10.1177/2048872617735808
doi:
Substances chimiques
CDKN1A protein, human
0
Cyclin-Dependent Kinase Inhibitor p21
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM