Effectiveness of seminal plasma in in vitro fertilisation treatment: a systematic review and meta-analysis.

Embryo Implantation / immunology Female Fertilization in Vitro / methods Humans Male Oocyte Retrieval / methods Pregnancy Pregnancy Rate Randomized Controlled Trials as Topic Semen / immunology Time Factors
ICSI Fertility implantation in vitro fertilization oocyte seminal plasma

Journal

BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741

Informations de publication

Date de publication:
Jan 2019
Historique:
accepted: 15 10 2017
pubmed: 28 10 2017
medline: 9 3 2019
entrez: 28 10 2017
Statut: ppublish

Résumé

With in vitro fertilization (IVF) techniques, only 20-25% of the transferred embryos lead to a pregnancy. To evaluate the beneficial effects of seminal plasma (SP) or semen applied at the time of oocyte aspiration or embryo transfer. Electronic databases were searched from their inception up to August 2017. We included all randomized controlled trials (RCTs) evaluating the effects of SP or semen in IVF treatment. Trials were considered if women were exposed to any kind of SP or semen (either SP/semen injection or sexual intercourse) around the time of oocyte pickup and embryo transfer. The primary outcome was clinical pregnancy rate (CPR). Eight RCTs on women undergoing IVF (2128 in total) were included in the meta-analysis. Women randomized in the intervention group had a significantly higher CPR compared with controls (30.0 versus 25.1%; RR 1.20; 95% CI, 1.04-1.39). No significant differences were found in the secondary outcomes, including livebirth rate, biochemical pregnancy, miscarriage, multiple pregnancies, and birth weight. The subgroup analyses (four RCTs, 780 participants), including only those RCTs in which prepared undiluted SP was injected just after oocyte pickup, conformed with the overall analysis for the primary outcome (46.3 versus 37.2%; RR 1.23; 95% CI, 1.05-1.45). Because intravaginal or intracervical SP application around the time of oocyte pickup is associated with higher CPR, local application SP may be considered as a potential treatment to improve implantation. SP at the time of oocyte pickup is associated with higher CPR.

Sections du résumé

BACKGROUND BACKGROUND
With in vitro fertilization (IVF) techniques, only 20-25% of the transferred embryos lead to a pregnancy.
OBJECTIVE OBJECTIVE
To evaluate the beneficial effects of seminal plasma (SP) or semen applied at the time of oocyte aspiration or embryo transfer.
SEARCH STRATEGY METHODS
Electronic databases were searched from their inception up to August 2017.
SELECTION CRITERIA METHODS
We included all randomized controlled trials (RCTs) evaluating the effects of SP or semen in IVF treatment. Trials were considered if women were exposed to any kind of SP or semen (either SP/semen injection or sexual intercourse) around the time of oocyte pickup and embryo transfer.
DATA COLLECTION AND ANALYSIS METHODS
The primary outcome was clinical pregnancy rate (CPR).
MAIN RESULTS RESULTS
Eight RCTs on women undergoing IVF (2128 in total) were included in the meta-analysis. Women randomized in the intervention group had a significantly higher CPR compared with controls (30.0 versus 25.1%; RR 1.20; 95% CI, 1.04-1.39). No significant differences were found in the secondary outcomes, including livebirth rate, biochemical pregnancy, miscarriage, multiple pregnancies, and birth weight. The subgroup analyses (four RCTs, 780 participants), including only those RCTs in which prepared undiluted SP was injected just after oocyte pickup, conformed with the overall analysis for the primary outcome (46.3 versus 37.2%; RR 1.23; 95% CI, 1.05-1.45).
CONCLUSION CONCLUSIONS
Because intravaginal or intracervical SP application around the time of oocyte pickup is associated with higher CPR, local application SP may be considered as a potential treatment to improve implantation.
TWEETABLE ABSTRACT CONCLUSIONS
SP at the time of oocyte pickup is associated with higher CPR.

Identifiants

DOI: 10.1111/1471-0528.15004 PMID: 29078039
pubmed: 29078039
doi: 10.1111/1471-0528.15004
doi:

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

220-225

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2017 Royal College of Obstetricians and Gynaecologists.

Auteurs

G Saccone (G)

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

A Di Spiezio Sardo (A)

Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

A Ciardulli (A)

Department of Obstetrics and Gynecology, University of Rome, Rome, Italy.

C Caissutti (C)

Department of Experimental Clinical and Medical Science, DISM, Clinic of Obstetrics and Gynecology, University of Udine, Udine, Italy.

M Spinelli (M)

Department of Clinical Research, University of Bern, Bern, Switzerland.

D Surbek (D)

Department of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.

M von Wolff (M)

Division of Gynecological Endocrinology and Reproductive Medicine, University Women's Hospital, Bern, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Implantation embryonnaire › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Techniques d'investigation › Techniques de reproduction › Techniques de reproduction assistée › Fécondation in vitro › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Techniques d'investigation › Techniques de reproduction › Techniques de reproduction assistée › Prélèvement d'ovocytes › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Taux de grossesse › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Sperme › Effectiveness of seminal plasma in in vitro...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Effectiveness of seminal plasma in in vitro...