Bioactive isoquinoline alkaloids from Cissampelos pareira
A549 Cells
Alkaloids
/ isolation & purification
Antineoplastic Agents, Phytogenic
/ isolation & purification
Aporphines
Cissampelos
/ chemistry
Humans
India
Isoquinolines
/ isolation & purification
KB Cells
Molecular Structure
Phytochemicals
/ isolation & purification
Plant Extracts
/ chemistry
Plant Roots
/ chemistry
Seasons
None
UPLC quantification
benzylisoquinoline alkaloids
cytotoxicity
Journal
Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
pubmed:
12
11
2017
medline:
18
6
2019
entrez:
12
11
2017
Statut:
ppublish
Résumé
The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5) and cycleanine (6). Magnoflorine (1) and magnocurarine (2) were isolated for the first time from C. pareira. A new, rapid, simple and sensitive UPLC method was developed for simultaneous quantification of five pure compounds (1-5). Seasonal variation study revealed higher content of these compounds during the rainy season. The chloroform (CPCF) and n-butanol (CPBF) fractions showed cytotoxic efficacy against KB cells. Among pure compounds, hayatinine (5) was found to be most active against KB and A549, while, cycleanine (6) against KB cells.
Identifiants
pubmed: 29126362
doi: 10.1080/14786419.2017.1402319
doi:
Substances chimiques
Alkaloids
0
Antineoplastic Agents, Phytogenic
0
Aporphines
0
Isoquinolines
0
Phytochemicals
0
Plant Extracts
0
cycleanine
518-94-5
curine
6037FRH2SX
magnocurarine
6801-40-7
isoquinoline
JGX76Y85M6
magnoflorine
NI8K6962K4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM