Noninvasive Cerebellar Stimulation as a Complement Tool to Pharmacotherapy.
ataxia
cerebellar TMS
cerebellar tDCS
cerebellum
non invasive neuromodulation
tDCS.
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
06
2017
revised:
09
10
2017
accepted:
06
11
2017
pubmed:
17
11
2017
medline:
11
4
2019
entrez:
17
11
2017
Statut:
ppublish
Résumé
Cerebellar ataxias represent a wide and heterogeneous group of diseases characterized by balance and coordination disturbance, dysarthria, dyssynergia and adyadococinesia, caused by a dysfunction in the cerebellum. In recent years there has been growing interest in discovering therapeutical strategy for specific forms of cerebellar ataxia. Together with pharmacological studies, there has been growing interest in non-invasive cerebellar stimulation techniques to improve ataxia and limb coordination. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-invasive techniques to modulate cerebro and cerebellar cortex excitability using magnetic or electric fields. Here we aim to review the most relevant studies regarding the application of TMS and tDCS for the treatment of cerebellar ataxia. As pharmacological strategies were shown to be effective in specific forms of cerebellar ataxia and are not devoid of collateral effects, non-invasive stimulation may represent a promising strategy to improve residual cerebellar circuits functioning and a complement tool to pharmacotherapy.
Sections du résumé
BACKGROUND
BACKGROUND
Cerebellar ataxias represent a wide and heterogeneous group of diseases characterized by balance and coordination disturbance, dysarthria, dyssynergia and adyadococinesia, caused by a dysfunction in the cerebellum. In recent years there has been growing interest in discovering therapeutical strategy for specific forms of cerebellar ataxia. Together with pharmacological studies, there has been growing interest in non-invasive cerebellar stimulation techniques to improve ataxia and limb coordination. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-invasive techniques to modulate cerebro and cerebellar cortex excitability using magnetic or electric fields.
METHODS
METHODS
Here we aim to review the most relevant studies regarding the application of TMS and tDCS for the treatment of cerebellar ataxia.
CONCLUSION
CONCLUSIONS
As pharmacological strategies were shown to be effective in specific forms of cerebellar ataxia and are not devoid of collateral effects, non-invasive stimulation may represent a promising strategy to improve residual cerebellar circuits functioning and a complement tool to pharmacotherapy.
Identifiants
pubmed: 29141551
pii: CN-EPUB-86862
doi: 10.2174/1570159X15666171114142422
pmc: PMC6341494
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
14-20Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
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