Pathological cut-offs of global and regional brain volume loss in multiple sclerosis.
Adolescent
Adult
Aged
Atrophy
/ pathology
Brain
/ diagnostic imaging
Corpus Callosum
/ diagnostic imaging
Disease Progression
Female
Gray Matter
/ diagnostic imaging
Humans
Longitudinal Studies
Magnetic Resonance Imaging
/ standards
Male
Middle Aged
Multiple Sclerosis
/ diagnosis
Sensitivity and Specificity
Thalamus
/ diagnostic imaging
Young Adult
MRI
Multiple sclerosis
brain atrophy
cut-off value
disability
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
17
11
2017
medline:
10
1
2020
entrez:
17
11
2017
Statut:
ppublish
Résumé
Volumetric MRI surrogate markers of disease progression are lacking. To establish cut-off values of brain volume loss able to discriminate between healthy controls and MS patients. In total, 386 patients after first demyelinating event suggestive of MS (CIS), 964 relapsing-remitting MS (RRMS) patients, 63 secondary-progressive MS (SPMS) patients and 58 healthy controls were included in this longitudinal study. A total of 11,438 MRI scans performed on the same MRI scanner with the same protocol were analysed. Annualised percentage changes of whole brain, grey matter, thalamus and corpus callosum volumes were estimated. We investigated cut-offs able to discriminate between healthy controls and MS patients. At a predefined specificity of 90%, the annualised percentage change cut-off of corpus callosum volume (-0.57%) was able to distinguish between healthy controls and patients with the highest sensitivity (51% in CIS, 48% in RRMS and 42% in SPMS patients). Lower sensitivities (22%-49%) were found for cut-offs of whole brain, grey matter and thalamic volume loss. Among CIS and RRMS patients, cut-offs were associated with greater accumulation of disability. We identified cut-offs of annualised global and regional brain volume loss rates able to discriminate between healthy controls and MS patients.
Sections du résumé
BACKGROUND
Volumetric MRI surrogate markers of disease progression are lacking.
OBJECTIVE
To establish cut-off values of brain volume loss able to discriminate between healthy controls and MS patients.
METHODS
In total, 386 patients after first demyelinating event suggestive of MS (CIS), 964 relapsing-remitting MS (RRMS) patients, 63 secondary-progressive MS (SPMS) patients and 58 healthy controls were included in this longitudinal study. A total of 11,438 MRI scans performed on the same MRI scanner with the same protocol were analysed. Annualised percentage changes of whole brain, grey matter, thalamus and corpus callosum volumes were estimated. We investigated cut-offs able to discriminate between healthy controls and MS patients.
RESULTS
At a predefined specificity of 90%, the annualised percentage change cut-off of corpus callosum volume (-0.57%) was able to distinguish between healthy controls and patients with the highest sensitivity (51% in CIS, 48% in RRMS and 42% in SPMS patients). Lower sensitivities (22%-49%) were found for cut-offs of whole brain, grey matter and thalamic volume loss. Among CIS and RRMS patients, cut-offs were associated with greater accumulation of disability.
CONCLUSION
We identified cut-offs of annualised global and regional brain volume loss rates able to discriminate between healthy controls and MS patients.
Identifiants
pubmed: 29143562
doi: 10.1177/1352458517742739
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM