Motor axon guidance in Drosophila.

Animals Axon Guidance Axons / metabolism Drosophila / cytology Drosophila Proteins / metabolism Motor Neurons / cytology
Axon guidance Beaten path Drosophila Frazzled Guidance receptor Motoneuron Motor neuron Motor system Netrin Plexin Receptor protein phosphatase Robo Sema Sidestep Slit Transcription Unc-5

Journal

Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332

Informations de publication

Date de publication:
01 2019
Historique:
received: 20 09 2017
accepted: 10 11 2017
pubmed: 21 11 2017
medline: 15 5 2019
entrez: 21 11 2017
Statut: ppublish

Résumé

The Drosophila motor system starts to assemble during embryonic development. It is composed of 30 muscles per abdominal hemisegment and 36 motor neurons assembling into nerve branches to exit the CNS, navigate within the muscle field and finally establish specific connections with their target muscles. Several families of guidance molecules that play a role controlling this process as well as transcriptional regulators that program the behavior of specific motor neuron have been identified. In this review we summarize the role of both groups of molecules in the motor system as well as their relationship where known. It is apparent that partially redundant guidance protein families and membrane molecules with different functional output direct guidance decisions cooperatively. Some distinct transcriptional regulators seem to control guidance of specific nerve branches globally directing the expression of groups of pathfinding molecules in all motor neurons within the same motor branch.

Identifiants

DOI: 10.1016/j.semcdb.2017.11.013 PMID: 29155221
pubmed: 29155221
pii: S1084-9521(17)30297-5
doi: 10.1016/j.semcdb.2017.11.013
pii:
doi:

Substances chimiques

Drosophila Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

36-47

Informations de copyright

Copyright © 2017 Elsevier Ltd. All rights reserved.

Auteurs

Aref Arzan Zarin (A)

Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA.

Juan-Pablo Labrador (JP)

Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland; Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. Electronic address: labradoj@tcd.ie.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Motor axon guidance in Drosophila.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Excroissance neuronale › Guidage axonal › Motor axon guidance in Drosophila.
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Motor axon guidance in Drosophila.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Motor axon guidance in Drosophila.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Motor axon guidance in Drosophila.
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Motor axon guidance in Drosophila.