Neural correlates of improvements in personality and behavior following a neurological event.
Behavior
Lesion
Neurological event
Personality
Journal
Neuropsychologia
ISSN: 1873-3514
Titre abrégé: Neuropsychologia
Pays: England
ID NLM: 0020713
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
05
06
2017
revised:
11
11
2017
accepted:
18
11
2017
pubmed:
23
11
2017
medline:
10
6
2021
entrez:
23
11
2017
Statut:
ppublish
Résumé
Research on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the current work, we investigated neuroanatomical correlates of positive personality and behavioral changes following a discrete neurological event (e.g., stroke, benign tumor resection). Patients (N = 97) were rated by a well-known family member or friend on five domains of personality and behavior: social behavior, irascibility, hypo-emotionality, distress, and executive functioning. Ratings were acquired during the chronic epoch of recovery, when psychological status was stabilized. We identified patients who showed positive changes in personality and behavior in one or more domains of functioning. Lesion analyses indicated that positive changes in personality and behavior were most consistently related to damage to the bilateral frontal polar regions and the right anterior dorsolateral prefrontal region. These findings support the conclusion that improvements in personality and behavior can occur after a neurological event, and that such changes have systematic neuroanatomical correlates. Patients who showed positive changes in personality and behavior following a neurological event were rated as having more disturbed functioning prior to the event. Our study may be taken as preliminary evidence that improvements in personality and behavior following a neurological event may involve dampening of (premorbidly) more extreme expressions of emotion.
Identifiants
pubmed: 29166593
pii: S0028-3932(17)30445-1
doi: 10.1016/j.neuropsychologia.2017.11.023
pmc: PMC6494695
mid: NIHMS1019698
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106579Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094258
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM108540
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007421
Pays : United States
Informations de copyright
Copyright © 2017 Elsevier Ltd. All rights reserved.
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