Translational bioinformatics in mental health: open access data sources and computational biomarker discovery.
biomarker discovery
mental health
open access
translational bioinformatics
Journal
Briefings in bioinformatics
ISSN: 1477-4054
Titre abrégé: Brief Bioinform
Pays: England
ID NLM: 100912837
Informations de publication
Date de publication:
21 05 2019
21 05 2019
Historique:
received:
01
08
2017
revised:
24
10
2017
pubmed:
1
12
2017
medline:
3
4
2020
entrez:
30
11
2017
Statut:
ppublish
Résumé
Mental illness is increasingly recognized as both a significant cost to society and a significant area of opportunity for biological breakthrough. As -omics and imaging technologies enable researchers to probe molecular and physiological underpinnings of multiple diseases, opportunities arise to explore the biological basis for behavioral health and disease. From individual investigators to large international consortia, researchers have generated rich data sets in the area of mental health, including genomic, transcriptomic, metabolomic, proteomic, clinical and imaging resources. General data repositories such as the Gene Expression Omnibus (GEO) and Database of Genotypes and Phenotypes (dbGaP) and mental health (MH)-specific initiatives, such as the Psychiatric Genomics Consortium, MH Research Network and PsychENCODE represent a wealth of information yet to be gleaned. At the same time, novel approaches to integrate and analyze data sets are enabling important discoveries in the area of mental and behavioral health. This review will discuss and catalog into an organizing framework the increasingly diverse set of MH data resources available, using schizophrenia as a focus area, and will describe novel and integrative approaches to molecular biomarker discovery that make use of mental health data.
Identifiants
pubmed: 29186302
pii: 4662948
doi: 10.1093/bib/bbx157
pmc: PMC6585382
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-856Subventions
Organisme : NLM NIH HHS
ID : K01 LM012529
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM012095
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM012806
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001117
Pays : United States
Informations de copyright
© The Author 2017. Published by Oxford University Press.
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