IL-1 family cytokines in cardiovascular disease.
Cardiovascular disease
Caspase 1
IL-1
IL-18
Inflammasome
Interleukin
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
03
08
2017
revised:
13
11
2017
accepted:
15
11
2017
pubmed:
5
12
2017
medline:
10
9
2020
entrez:
5
12
2017
Statut:
ppublish
Résumé
The interleukin (IL)-1 family is a group of cytokines crucially involved in regulating immune responses to infectious challenges and sterile insults. The family consists of the eponymous pair IL-1α and IL-1β, IL-18, IL-33, IL-37, IL-38, and several isoforms of IL-36. In addition, two endogenous inhibitors of functional receptor binding, IL-1R antagonist (IL-1Ra) and IL-36Ra complete the family. To gain biological activity IL-1β and IL-18 require processing by the protease caspase-1 which is associated with the multi-protein complex inflammasome. Numerous clinical association studies and experimental approaches have implicated members of the IL-1 family, their receptors, or component of the processing machinery in underlying processes of cardiovascular diseases (CVDs). Here we summarize the current state of knowledge regarding the pro-inflammatory and disease-modulating role of the IL-1 family in atherosclerosis, myocardial infarction, aneurysm, stroke, and other CVDs. We discuss clinical evidence, experimental approaches and lastly lend a perspective on currently developing therapeutic strategies involving the IL-1 family in CVD.
Identifiants
pubmed: 29198612
pii: S1043-4666(17)30351-4
doi: 10.1016/j.cyto.2017.11.009
pii:
doi:
Substances chimiques
Cytokines
0
IL1A protein, human
0
IL1B protein, human
0
Inflammasomes
0
Interleukin-1alpha
0
Interleukin-1beta
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
154215Informations de copyright
Copyright © 2017 Elsevier Ltd. All rights reserved.