Regulation of pro- and anti-atherogenic cytokines.
Atherosclerosis
Cytokines
Inflammation
RNA binding protein
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
09
06
2017
revised:
29
08
2017
accepted:
26
09
2017
pubmed:
10
12
2017
medline:
10
9
2020
entrez:
10
12
2017
Statut:
ppublish
Résumé
Despite advances in prevention and treatment, vascular diseases continue to account for significant morbidity and mortality in the developed world. Incidence is expected to worsen as the number of patients with common co-morbidities linked with atherosclerotic vascular disease, such as obesity and diabetes, continues to increase, reaching epidemic proportions. Atherosclerosis is a lipid-driven vascular inflammatory disease involving multiple cell types in various stages of inflammation, activation, apoptosis, and necrosis. One commonality among these cell types is that they are activated and communicate with each other in a paracrine fashion via a complex network of cytokines. Cytokines mediate atherogenesis by stimulating expression of numerous proteins necessary for induction of a host of cellular responses, including inflammation, extravasation, proliferation, apoptosis, and matrix production. Cytokine expression is regulated by a number of transcriptional and post-transcriptional mechanisms. In this context, proteins that control and fine-tune cytokine expression can be considered key players in development of atherosclerosis and also represent targets for rational drug therapy to combat this disease. This review will describe the cellular and molecular mechanisms that drive atherosclerotic plaque progression and present key cytokines that participate in this process. We will also describe RNA binding proteins that mediate cytokine mRNA stability and regulate cytokine abundance. Identification and characterization of the cytokines and proteins that regulate their abundance are essential to our ability to identify therapeutic approaches to ameliorate atherosclerotic vascular disease.
Identifiants
pubmed: 29221669
pii: S1043-4666(17)30289-2
doi: 10.1016/j.cyto.2017.09.031
pmc: PMC5988906
mid: NIHMS925943
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
154175Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL115575
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117724
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141108
Pays : United States
Informations de copyright
Copyright © 2017 Elsevier Ltd. All rights reserved.
Références
EMBO J. 2000 Aug 1;19(15):4154-63
pubmed: 10921895
Cell. 1996 Feb 9;84(3):331-4
pubmed: 8608586
Circ Res. 2013 Oct 12;113(9):1065-75
pubmed: 23963726
Scand J Immunol. 1999 Jul;50(1):25-30
pubmed: 10404048
Atherosclerosis. 2004 Feb;172(2):211-8
pubmed: 15019530
Pharmacol Ther. 2007 Apr;114(1):56-73
pubmed: 17320967
Am J Pathol. 2008 Jun;172(6):1500-8
pubmed: 18467709
Nat Rev Rheumatol. 2009 Oct;5(10):578-82
pubmed: 19798034
J Cell Biol. 1999 Dec 27;147(7):1431-42
pubmed: 10613902
J Biol Chem. 2005 Jun 17;280(24):22819-26
pubmed: 15824116
Micron. 2006;37(3):208-22
pubmed: 16360317
Ann Med. 2011 Nov;43(7):503-11
pubmed: 21585245
J Biol Chem. 2008 Aug 15;283(33):22457-63
pubmed: 18559347
J Mol Cell Cardiol. 2010 Oct;49(4):647-54
pubmed: 20451530
Am J Pathol. 2008 Sep;173(3):901-9
pubmed: 18669613
Free Radic Biol Med. 2000 Jun 15;28(12):1697-707
pubmed: 10946211
Physiol Rev. 2006 Apr;86(2):515-81
pubmed: 16601268
Mol Cell Biol. 1998 Dec;18(12):6879-84
pubmed: 9819376
J Rheumatol. 2005 Jul;32(7):1213-8
pubmed: 15996054
J Clin Invest. 1997 Jun 1;99(11):2752-61
pubmed: 9169506
Cell. 2013 May 9;153(4):869-81
pubmed: 23663784
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1670-4
pubmed: 2419912
J Immunol. 2010 Jul 15;185(2):1222-9
pubmed: 20543107
Immunity. 1999 Mar;10(3):387-98
pubmed: 10204494
J Clin Invest. 1997 Dec 1;100(11):2680-90
pubmed: 9389731
J Intern Med. 2017 Apr;281(4):383-397
pubmed: 28194913
Atherosclerosis. 2012 Feb;220(2):329-36
pubmed: 22062588
Int J Cardiol. 2012 Jan 26;154(2):187-9
pubmed: 22104996
Circulation. 1998 Jan 27;97(3):242-4
pubmed: 9462524
Ann Rheum Dis. 2009 Apr;68(4):604-6
pubmed: 19286907
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4560-5
pubmed: 15070757
J Am Heart Assoc. 2013 May 20;2(3):e000117
pubmed: 23688675
Nat Commun. 2016 Mar 31;7:10846
pubmed: 27029405
J Immunol. 2004 Dec 1;173(11):6712-8
pubmed: 15557163
J Dent Res. 2012 Jul;91(7):651-8
pubmed: 22302144
Triangle. 1970;9(6):200-8
pubmed: 5504878
Am J Pathol. 2016 May;186(5):1361-74
pubmed: 26952642
Nat Med. 2006 Feb;12(2):178-80
pubmed: 16462800
RNA. 2006 Jun;12(6):1084-91
pubmed: 16601207
Nat Rev Rheumatol. 2016 Jan;12(1):49-62
pubmed: 26656660
Wiley Interdiscip Rev RNA. 2010 Nov-Dec;1(3):457-73
pubmed: 21956942
Circ Res. 2001 Nov 9;89(10):930-4
pubmed: 11701621
FASEB J. 2001 Dec;15(14):2730-2
pubmed: 11687507
Atherosclerosis. 2003 Oct;170(2):205-11
pubmed: 14612199
Stroke. 2015 Mar;46(3):793-9
pubmed: 25649806
Nat Rev Immunol. 2013 Oct;13(10):709-21
pubmed: 23995626
Circ Res. 2001 Sep 28;89(7):E41-5
pubmed: 11577031
Am J Pathol. 2003 Sep;163(3):1117-25
pubmed: 12937153
J Immunol. 1989 Jul 1;143(1):15-22
pubmed: 2525146
Ann N Y Acad Sci. 1995 Jan 17;748:501-7
pubmed: 7695193
Immunity. 1997 Mar;6(3):315-25
pubmed: 9075932
Thromb Haemost. 2014 Aug;112(2):332-41
pubmed: 24816772
Am J Pathol. 2007 Dec;171(6):2040-7
pubmed: 18055554
Am J Physiol Cell Physiol. 2011 Apr;300(4):C896-906
pubmed: 21209363
Nat Med. 1995 Jan;1(1):74-9
pubmed: 7584958
J Biol Chem. 1996 Mar 29;271(13):7767-73
pubmed: 8631819
Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C255-65
pubmed: 23596173
Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):734-42
pubmed: 10073981
Proc Natl Acad Sci U S A. 1985 Jan;82(2):416-20
pubmed: 3855559
Circ Res. 2002 Feb 8;90(2):E34-8
pubmed: 11834721
J Immunol. 1990 Dec 1;145(11):3796-806
pubmed: 2147202
Atherosclerosis. 1995 May;115(1):89-98
pubmed: 7545398
Atherosclerosis. 2006 Sep;188(1):19-27
pubmed: 16300768
Vascul Pharmacol. 2015 Sep;72:108-17
pubmed: 25956731
Mol Cell Biol. 2001 Feb;21(3):721-30
pubmed: 11154260
Crit Rev Eukaryot Gene Expr. 2010;20(2):87-103
pubmed: 21133840
Am J Pathol. 2000 Dec;157(6):1819-24
pubmed: 11106554
J Immunol. 1998 Oct 1;161(7):3400-7
pubmed: 9759857
Circulation. 1994 May;89(5):2462-78
pubmed: 8181179
Atherosclerosis. 1999 Jul;145(1):33-43
pubmed: 10428293
Pharmacol Rev. 2003 Mar;55(1):133-66
pubmed: 12615956
J Biol Chem. 2000 Dec 29;275(52):41035-48
pubmed: 10969071
Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1048-54
pubmed: 26249698
Circulation. 2004 Nov 30;110(22):3493-500
pubmed: 15557373
Thromb Haemost. 1997 Jul;78(1):200-4
pubmed: 9198153
J Biol Chem. 1998 Mar 13;273(11):6417-23
pubmed: 9497373
Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2137-42
pubmed: 15345516
Nat Rev Immunol. 2016 Nov;16(11):676-689
pubmed: 27640624
Inflamm Res. 2005 Oct;54(10):395-411
pubmed: 16283107
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10193-7
pubmed: 8234276
Circ Res. 1999 Oct 15;85(8):e17-24
pubmed: 10521249
N Engl J Med. 1999 Jan 14;340(2):115-26
pubmed: 9887164
Atherosclerosis. 2007 Nov;195(1):31-8
pubmed: 17173923
Gene Ther. 2004 Dec;11(24):1772-9
pubmed: 15496963
Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2316-24
pubmed: 23950143
Cytokine Growth Factor Rev. 2009 Apr;20(2):125-35
pubmed: 19041276
Circulation. 2011 Nov 29;124(22):2433-43, 1-7
pubmed: 22064596
Inflamm Res. 2009 Nov;58(11):809-18
pubmed: 19533020
Int Immunol. 2004 Mar;16(3):501-8
pubmed: 14978023
Circ Res. 2009 Jan 30;104(2):e9-18
pubmed: 19096025
Am J Pathol. 1996 Aug;149(2):359-66
pubmed: 8701976
Genesis. 2002 Mar;32(3):218-30
pubmed: 11892011
Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2364-7
pubmed: 10521365
Circulation. 2002 Jul 2;106(1):24-30
pubmed: 12093765
Eur Heart J. 2002 Mar;23 (5):376-83
pubmed: 11846495
Curr Opin Lipidol. 2005 Oct;16(5):518-24
pubmed: 16148536
Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):637-44
pubmed: 23307873
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1596-601
pubmed: 15665085
J Exp Med. 2008 Feb 18;205(2):339-46
pubmed: 18268038
J Immunol. 1996 Apr 15;156(8):3043-50
pubmed: 8609427
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):167-75
pubmed: 20966397
Eur Heart J. 2017 May 7;38(18):1380-1388
pubmed: 28064149
Mol Med. 2003 Jan-Feb;9(1-2):10-7
pubmed: 12765335
Circulation. 2005 Aug 16;112(7):1054-62
pubmed: 16103256
Clin Immunol. 2008 Apr;127(1):89-97
pubmed: 18294918
PLoS One. 2007 Aug 22;2(8):e779
pubmed: 17712427
Circulation. 2017 Mar 7;135(10 ):e146-e603
pubmed: 28122885
Front Biosci. 2008 Jan 01;13:453-61
pubmed: 17981560
Angiology. 2004 May-Jun;55(3):289-94
pubmed: 15156262
Arthritis Rheum. 2005 Apr;52(4):1037-46
pubmed: 15818686
Cardiovasc Res. 2003 Jul 1;59(1):234-40
pubmed: 12829194
Blood. 2012 Jan 19;119(3):651-65
pubmed: 22053109
Int Immunol. 2013 Nov;25(11):615-22
pubmed: 24154816
Nucleic Acids Res. 1996 Nov 15;24(22):4407-14
pubmed: 8948631
Circulation. 2011 Mar 15;123(10):1083-91
pubmed: 21357823
Immunity. 1996 May;4(5):445-54
pubmed: 8630730
Circ Res. 2008 Nov 7;103(10):1128-38
pubmed: 18818407
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18460-5
pubmed: 19015529
Atherosclerosis. 2015 Oct;242(2):506-14
pubmed: 26298743
Arthritis Rheum. 2007 Sep;56(9):2905-12
pubmed: 17763428
Blood. 2003 Dec 1;102(12):4052-8
pubmed: 12920022