Natural killer cells and anti-tumor immunity.

Animals Cell Cycle Checkpoints / genetics Humans Immunity, Innate / physiology Immunotherapy / methods Killer Cells, Natural / physiology Neoplasms / immunology Suppressor of Cytokine Signaling Proteins / physiology
CIS Cancer IL-15 ILCs NK cells SOCS proteins SOCS2

Journal

Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289

Informations de publication

Date de publication:
06 2019
Historique:
received: 29 07 2017
revised: 20 11 2017
accepted: 01 12 2017
pubmed: 14 12 2017
medline: 29 10 2019
entrez: 14 12 2017
Statut: ppublish

Résumé

Immune checkpoint inhibitors harness the power of the immune system to fight cancer. The clinical success achieved with antibodies against the inhibitory T cell receptors PD-1 and CTLA4 has focused attention on the possibility of manipulating other immune cells, in particular those involved in innate immunity. Here we review the role of innate lymphoid cells (ILCs) and their contribution to tumor immunity. As the prototypical ILC, the natural killer (NK) cell has an intrinsic ability to detect and kill cancer cells. NK cells are dependent on the cytokine interleukin (IL)-15 for their development and effector activity. We discuss the role of the Suppressor of cytokine (SOCS) proteins in negatively regulating IL-15 and NK cell responses and the potential for targeting these small intracellular regulators as new immune checkpoints.

Identifiants

DOI: 10.1016/j.molimm.2017.12.002 PMID: 29233542
pubmed: 29233542
pii: S0161-5890(17)30595-3
doi: 10.1016/j.molimm.2017.12.002
pii:
doi:

Substances chimiques

Suppressor of Cytokine Signaling Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

40-47

Informations de copyright

Copyright © 2017 Elsevier Ltd. All rights reserved.

Auteurs

Sandra E Nicholson (SE)

Walter and Eliza Hall Institute of Medical Research, Melbourne, 3052, Australia; and Department of Medical Biology, University of Melbourne, Melbourne, 3010, Australia. Electronic address: snicholson@wehi.edu.au.

Narelle Keating (N)

Walter and Eliza Hall Institute of Medical Research, Melbourne, 3052, Australia; and Department of Medical Biology, University of Melbourne, Melbourne, 3010, Australia.

Gabrielle T Belz (GT)

Walter and Eliza Hall Institute of Medical Research, Melbourne, 3052, Australia; and Department of Medical Biology, University of Melbourne, Melbourne, 3010, Australia. Electronic address: belz@wehi.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Natural killer cells and anti-tumor immunity.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Points de contrôle du cycle cellulaire › Natural killer cells and anti-tumor immunity.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Natural killer cells and anti-tumor immunity.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Natural killer cells and anti-tumor immunity.
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Natural killer cells and anti-tumor immunity.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › Natural killer cells and anti-tumor immunity.
questionsmedicales.fr › Tumeurs › Natural killer cells and anti-tumor immunity.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines SOCS › Natural killer cells and anti-tumor immunity.