Commissural axon navigation in the spinal cord: A repertoire of repulsive forces is in command.
Attraction
Axon guidance
Commissural axon
Growth cone
Guidance signaling
Midline crossing
Repulsion
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
04
10
2017
revised:
11
12
2017
accepted:
11
12
2017
pubmed:
27
12
2017
medline:
15
5
2019
entrez:
27
12
2017
Statut:
ppublish
Résumé
The navigation of commissural axons in the developing spinal cord has attracted multiple studies over the years. Many important concepts emerged from these studies which have enlighten the general mechanisms of axon guidance. The navigation of commissural axons is regulated by a series of cellular territories which provides the diverse guidance information necessary to ensure the successive steps of their pathfinding towards, across, and away from the ventral midline. In this review, we discuss how repulsive forces, by propelling, channelling, and confining commissural axon navigation, bring key contributions to the formation of this neuronal projection.
Identifiants
pubmed: 29277684
pii: S1084-9521(17)30286-0
doi: 10.1016/j.semcdb.2017.12.010
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-12Informations de copyright
Copyright © 2017 Elsevier Ltd. All rights reserved.