Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana.
None
Clusiaceae
antimicrobial
cytotoxic activity
garcixanthone A
xanthones
Journal
Journal of Asian natural products research
ISSN: 1477-2213
Titre abrégé: J Asian Nat Prod Res
Pays: England
ID NLM: 100888334
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
pubmed:
9
1
2018
medline:
28
8
2019
entrez:
9
1
2018
Statut:
ppublish
Résumé
A new prenylated xanthone, garcixanthone A (5), together with eight known compounds, mangostanaxanthones I (1) and II (2), garcinone E (3), β-mangostin (4), 8-hydroxycudraxanthone G (6), garcinone C (7), cudraxanthone G (8), and (-)-epicatechin (9) were isolated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (family Clusiaceae). Their structures were verified on the basis of spectroscopic data interpretation as well as comparison with the literature. The cytotoxic and antimicrobial activities of the new compound were assessed using sulforhodamine B (SRB) and agar disk diffusion assays, respectively. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma (A549) and breast carcinoma (MCF7) cell lines with IC
Identifiants
pubmed: 29307236
doi: 10.1080/10286020.2017.1423058
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Antineoplastic Agents, Phytogenic
0
Xanthones
0
garcixanthone A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM