Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.
Human
P450 2A13
P450 2A6
P450s
flavanone
flavone
oxidation
Journal
Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
10
1
2018
medline:
6
3
2019
entrez:
10
1
2018
Statut:
ppublish
Résumé
1. We previously reported that flavone and flavanone interact spectrally with cytochrome P450 (P450 or CYP) 2A6 and 2A13 and other human P450s and inhibit catalytic activities of these P450 enzymes. In this study, we studied abilities of CYP1A1, 1A2, 1B1, 2A6, 2A13, 2C9 and 3A4 to oxidize flavone and flavanone. 2. Human P450s oxidized flavone to 6- and 5-hydroxylated flavones, seven uncharacterized mono-hydroxylated flavones, and five di-hydroxylated flavones. CYP2A6 was most active in forming 6-hydroxy- and 5-hydroxyflavones and several mono- and di-hydroxylated products. 3. CYP2A6 was also very active in catalyzing flavanone to form 2'- and 6-hydroxyflavanones, the major products, at turnover rates of 4.8 min
Identifiants
pubmed: 29310511
doi: 10.1080/00498254.2018.1426133
pmc: PMC6430112
mid: NIHMS1007478
doi:
Substances chimiques
Flavanones
0
Flavones
0
Cytochrome P-450 Enzyme System
9035-51-2
Cytochrome P-450 CYP2A6
EC 1.14.14.1
flavone
S2V45N7G3B
flavanone
WX22P730FB
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-142Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM118122
Pays : United States
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