Spectroscopic evaluation of synthesized 5β-dihydrocortisol and 5β-dihydrocortisol acetate binding mechanism with human serum albumin and their role in anticancer activity.
Acetates
/ chemical synthesis
Antineoplastic Agents
/ pharmacology
Binding Sites
Cell Death
/ drug effects
Circular Dichroism
HEK293 Cells
Humans
Hydrocortisone
/ analogs & derivatives
MCF-7 Cells
Molecular Docking Simulation
Molecular Dynamics Simulation
Protein Structure, Secondary
Serum Albumin, Human
/ chemistry
Spectrometry, Fluorescence
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis
Thermodynamics
5β-dihydrocortisol
apoptosis
fluorescence quenching
molecular docking
molecular dynamics simulations
protein conformations
Journal
Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
30
1
2018
medline:
4
9
2019
entrez:
30
1
2018
Statut:
ppublish
Résumé
Our study focus on the biological importance of synthesized 5β-dihydrocortisol (Dhc) and 5β-dihydrocortisol acetate (DhcA) molecules, the cytotoxic study was performed on breast cancer cell line (MCF-7) normal human embryonic kidney cell line (HEK293), the IC
Identifiants
pubmed: 29375009
doi: 10.1080/07391102.2018.1433554
doi:
Substances chimiques
Acetates
0
Antineoplastic Agents
0
5-dihydrocortisol
516-41-6
Hydrocortisone
WI4X0X7BPJ
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM