Gut microbiota, hypertension and chronic kidney disease: Recent advances.

Animals Gastrointestinal Microbiome Humans Hypertension / metabolism Probiotics / therapeutic use Renal Insufficiency, Chronic / metabolism
Blood pressure Ckd GLP-1 Inflammation Probiotics TLR-4

Journal

Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422

Informations de publication

Date de publication:
06 2019
Historique:
received: 25 09 2017
revised: 29 12 2017
accepted: 22 01 2018
pubmed: 30 1 2018
medline: 24 3 2020
entrez: 30 1 2018
Statut: ppublish

Résumé

A large number of different microbial species populates intestine. Extensive research has studied the entire microbial population and their genes (microbiome) by using metagenomics, metatranscriptomics and metabolomic analysis. Studies suggest that the imbalances of the microbial community causes alterations in the intestinal homeostasis, leading to repercussions on other systems: metabolic, nervous, cardiovascular, immune. These studies have also shown that alterations in the structure and function of the gut microbiota play a key role in the pathogenesis and complications of Hypertension (HTN) and Chronic Kidney Disease (CKD). Increased blood pressure (BP) and CKD are two leading risk factors for cardiovascular disease and their treatment represents a challenge for the clinicians. In this Review, we discuss mechanisms whereby gut microbiota (GM) and its metabolites act on downstream cellular targets to contribute to the pathogenesis of HTN and CKD, and potential therapeutic implications.

Identifiants

DOI: 10.1016/j.phrs.2018.01.013 PMID: 29378252
pubmed: 29378252
pii: S1043-6618(17)31208-2
doi: 10.1016/j.phrs.2018.01.013
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

390-408

Informations de copyright

Copyright © 2018. Published by Elsevier Ltd.

Auteurs

Antonio Sircana (A)

Unità Operativa di Cardiologia, Azienda Ospedaliero Universitaria, Sassari, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Franco De Michieli (F)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Renato Parente (R)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Luciana Framarin (L)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Nicola Leone (N)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Mara Berrutti (M)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Elena Paschetta (E)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Daria Bongiovanni (D)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy.

Giovanni Musso (G)

HUMANITAS Gradenigo, University of Turin, Turin, Italy; Department of Medical Sciences, San Giovanni Battista Hospital, Turin, Italy. Electronic address: giovanni_musso@yahoo.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gut microbiota, hypertension and chronic...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Gut microbiota, hypertension and chronic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gut microbiota, hypertension and chronic...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Gut microbiota, hypertension and chronic...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Probiotiques › Gut microbiota, hypertension and chronic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Gut microbiota, hypertension and chronic...