Diagnostic value of stress thallium-201/rest technetium-99m-sestamibi sequential dual isotope high-speed myocardial perfusion imaging for the detection of haemodynamically relevant coronary artery stenosis.
Adolescent
Adult
Aged
Aged, 80 and over
Child
Coronary Angiography
Coronary Stenosis
/ diagnostic imaging
Exercise Test
Female
Fractional Flow Reserve, Myocardial
Humans
Male
Middle Aged
Myocardial Perfusion Imaging
Radiopharmaceuticals
Sensitivity and Specificity
Technetium Tc 99m Sestamibi
Thallium Radioisotopes
Young Adult
Coronary artery disease
SPECT
dual isotope
fractional flow reserve
new camera CZT
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
08
2017
revised:
04
01
2018
pubmed:
31
1
2018
medline:
22
9
2020
entrez:
31
1
2018
Statut:
ppublish
Résumé
The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR). Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of ≥ 90% stenosis/occlusion or fractional flow reserve ≤ 0.80 for coronary stenosis ≥ 50%. FFR was measured in 69 of 162 coronary vessels, with 1.28 ± 0.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory. DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.
Sections du résumé
BACKGROUND
The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR).
METHODS
Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of ≥ 90% stenosis/occlusion or fractional flow reserve ≤ 0.80 for coronary stenosis ≥ 50%.
RESULTS
FFR was measured in 69 of 162 coronary vessels, with 1.28 ± 0.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory.
CONCLUSIONS
DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.
Identifiants
pubmed: 29380286
doi: 10.1007/s12350-018-1189-8
pii: 10.1007/s12350-018-1189-8
doi:
Substances chimiques
Radiopharmaceuticals
0
Thallium Radioisotopes
0
Technetium Tc 99m Sestamibi
971Z4W1S09
Thallium-201
H91Z8HBK1B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1269-1279Commentaires et corrections
Type : CommentIn
Type : CommentIn
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