Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes.

Animals Cats Cytochrome P-450 Enzyme System / metabolism Dogs Metabolic Clearance Rate Microsomes, Liver / metabolism Veterinary Drugs / pharmacokinetics
Microsome canine cytochrome P450 feline intrinsic clearance parallel tube predicted hepatic clearance well-stirred

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Feb 2019
Historique:
pubmed: 7 2 2018
medline: 6 3 2019
entrez: 7 2 2018
Statut: ppublish

Résumé

1. Known cytochrome P450 (CYP) substrates in humans are used in veterinary medicine, with limited knowledge of the similarity or variation in CYP metabolism. Comparison of canine and feline CYP metabolism via liver microsomes report that human CYP probes and inhibitors demonstrate differing rates of intrinsic clearance (CL

Identifiants

DOI: 10.1080/00498254.2018.1437933 PMID: 29405805
pubmed: 29405805
doi: 10.1080/00498254.2018.1437933
doi:

Substances chimiques

Veterinary Drugs 0
Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

177-186

Auteurs

Marike Visser (M)

a VMRD Global Therapeutics, Zoetis , Kalamazoo , MI , USA.

Matthew J Zaya (MJ)

b VMRD-PDMA, Zoetis , Kalamazoo , MI , USA.

Charles W Locuson (CW)

c Takeda Pharmaceuticals International Co , Cambridge , MA , USA.

Dawn M Boothe (DM)

d College of Veterinary Medicine, Auburn University , Auburn , AL , USA.

Dawn A Merritt (DA)

e VMRD Lab Sciences, Zoetis , Kalamazoo , MI , USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Comparison of predicted intrinsic hepatic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Feliformia › Felidae › Felis › Chats › Comparison of predicted intrinsic hepatic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Comparison of predicted intrinsic hepatic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Comparison of predicted intrinsic hepatic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Taux de clairance métabolique › Comparison of predicted intrinsic hepatic...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Comparison of predicted intrinsic hepatic...
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments vétérinaires › Comparison of predicted intrinsic hepatic...