Endothelial Nanomechanics in the Context of Endothelial (Dys)function and Inflammation.
cortical stiffness
endothelial dysfunction
inflammation
nanomechanics
nitric oxide
Journal
Antioxidants & redox signaling
ISSN: 1557-7716
Titre abrégé: Antioxid Redox Signal
Pays: United States
ID NLM: 100888899
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
pubmed:
13
2
2018
medline:
17
6
2020
entrez:
14
2
2018
Statut:
ppublish
Résumé
Stiffness of endothelial cells is closely linked to the function of the vasculature as it regulates the release of vasoactive substances such as nitric oxide (NO) and reactive oxygen species. The outer layer of endothelial cells, consisting of the glycocalyx above and the cortical zone beneath the plasma membrane, is a vulnerable compartment able to adapt its nanomechanical properties to any changes of forces exerted by the adjacent blood stream. Sustained stiffening of this layer contributes to the development of endothelial dysfunction and vascular pathologies. Recent Advances: The development of specific techniques to quantify the mechanical properties of cells enables the detailed investigation of the mechanistic link between structure and function of cells. Challenging the mechanical stiffness of cells, for instance, by inflammatory mediators can lead to the development of endothelial dysfunction. Prevention of sustained stiffening of the outer layer of endothelial cells in turn improves endothelial function. The mechanical properties of cells can be used as critical marker and test system for the proper function of the vascular system. Pharmacological substances, which are able to improve endothelial nanomechanics and function, could take a new importance in the prevention and treatment of vascular diseases. Thus, detailed knowledge acquisition about the structure/function relationship of endothelial cells and the underlying signaling pathways should be promoted.
Identifiants
pubmed: 29433330
doi: 10.1089/ars.2017.7327
pmc: PMC6354603
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
945-959Références
Pflugers Arch. 2014 May;466(5):851-9
pubmed: 24046153
FASEB J. 2016 Jan;30(1):45-53
pubmed: 26324851
Am J Physiol Lung Cell Mol Physiol. 2011 Sep;301(3):L353-60
pubmed: 21705487
Biochem Biophys Res Commun. 2007 Sep 21;361(2):462-7
pubmed: 17651694
Sci Rep. 2016 Feb 11;6:20989
pubmed: 26863988
J Struct Biol. 2008 Mar;161(3):459-68
pubmed: 17923421
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7765-70
pubmed: 11438729
Pflugers Arch. 2007 Jun;454(3):345-59
pubmed: 17256154
FASEB J. 2007 Aug;21(10):2389-99
pubmed: 17426066
Exp Cell Res. 2015 Nov 15;339(1):90-5
pubmed: 26364737
Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R143-8
pubmed: 12663256
Nat Med. 2012 Aug;18(8):1217-23
pubmed: 22820644
PLoS One. 2015 Jan 09;10(1):e0117133
pubmed: 25575016
Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):288-95
pubmed: 25147339
J Mol Cell Cardiol. 2011 Sep;51(3):419-27
pubmed: 21741389
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):9944-9
pubmed: 20463286
Circ Res. 2009 Jun 5;104(11):1318-25
pubmed: 19443840
Sci Signal. 2008 Oct 07;1(40):pt8
pubmed: 18840877
Ultramicroscopy. 2006 Jun-Jul;106(8-9):637-44
pubmed: 16675123
Physiol Rep. 2015 Dec;3(12):
pubmed: 26634902
Annu Rev Biomed Eng. 2015;17:113-141
pubmed: 26643020
J Cell Sci. 2014 Oct 15;127(Pt 20):4470-82
pubmed: 25107367
Cell Tissue Res. 2014 Mar;355(3):727-37
pubmed: 24643677
Micron. 2006;37(1):1-13
pubmed: 16171998
J Leukoc Biol. 2015 Oct;98(4):503-15
pubmed: 25979432
Hypertension. 2011 Feb;57(2):146-7
pubmed: 21149825
J Clin Anesth. 1988;1(2):135-45
pubmed: 3078530
Sci Rep. 2016 Jun 29;6:26767
pubmed: 27353721
Curr Opin Lipidol. 2005 Oct;16(5):507-11
pubmed: 16148534
Nanoscale. 2013 May 21;5(10):4094-104
pubmed: 23535827
Atherosclerosis. 2009 Jan;202(1):296-303
pubmed: 18550063
J Biol Chem. 2012 Mar 16;287(12):8782-91
pubmed: 22298783
Hypertension. 2010 Jul;56(1):17-21
pubmed: 20479337
Integr Biol (Camb). 2014 Mar;6(3):338-47
pubmed: 24480876
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7988-95
pubmed: 12810946
Curr Opin Anaesthesiol. 2009 Apr;22(2):155-62
pubmed: 19307890
Stem Cell Res Ther. 2015 May 27;6:103
pubmed: 26012510
Am J Physiol Cell Physiol. 2011 Jan;300(1):C146-54
pubmed: 20861463
Free Radic Biol Med. 2017 Aug;109:48-60
pubmed: 28108279
Pflugers Arch. 2010 May;459(6):793-806
pubmed: 20012875
Front Physiol. 2015 Jun 30;6:188
pubmed: 26175691
Biophys J. 2015 Mar 24;108(6):1330-1340
pubmed: 25809247
PLoS One. 2009 Nov 26;4(11):e8045
pubmed: 19956681
J Clin Invest. 1997 May 1;99(9):2062-70
pubmed: 9151776
Microcirculation. 2013 Feb;20(2):149-57
pubmed: 22963321
Circ Res. 2003 Apr 4;92(6):592-4
pubmed: 12637366
Cell Adh Migr. 2014;8(2):67-75
pubmed: 24621576
Biosens Bioelectron. 1996;11(3):281-94
pubmed: 8562009
Microvasc Res. 2009 Jan;77(1):53-63
pubmed: 19028505
Diabetologia. 2007 Jun;50(6):1288-93
pubmed: 17415544
Blood. 2001 Feb 1;97(3):660-8
pubmed: 11157482
Biochim Biophys Acta. 2010 Dec;1802(12):1193-202
pubmed: 20302930
Cardiovasc Res. 2013 Jul 15;99(2):260-8
pubmed: 23572234
Shock. 2008 Dec;30(6):623-7
pubmed: 18497712
Resuscitation. 2012 Jun;83(6):715-20
pubmed: 22306259
Annu Rev Biomed Eng. 2014 Jul 11;16:505-32
pubmed: 24905872
Am J Physiol Cell Physiol. 2003 Jun;284(6):C1542-9
pubmed: 12734108
Am J Physiol Lung Cell Mol Physiol. 2012 Jun 15;302(12):L1242-9
pubmed: 22505668
PLoS One. 2013 Nov 20;8(11):e80905
pubmed: 24278345
Cell Biol Int. 2005 Mar;29(3):245-8
pubmed: 15908238
Circ Res. 1996 Sep;79(3):581-9
pubmed: 8781491
PLoS One. 2012;7(3):e32418
pubmed: 22412870
Circ Res. 2005 Mar 18;96(5):488-500
pubmed: 15774861
Nephrol Dial Transplant. 2005 Mar;20(3):485-90
pubmed: 15701673
Biophys J. 2001 Mar;80(3):1124-40
pubmed: 11222278
Free Radic Biol Med. 2017 Aug;109:22-32
pubmed: 28336130
J Cell Biol. 2001 Jul 9;154(1):147-60
pubmed: 11448997
J Clin Invest. 2013 Feb;123(2):540-1
pubmed: 23485580
Shock. 2015 May;43(5):512-7
pubmed: 25565639
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2829-34
pubmed: 19202069
Pflugers Arch. 2011 Oct;462(4):519-28
pubmed: 21796337
Am J Physiol. 1994 Mar;266(3 Pt 1):C628-36
pubmed: 8166225
Blood. 2009 Aug 13;114(7):1387-95
pubmed: 19491394
Nanomedicine. 2015 Aug;11(6):1521-30
pubmed: 25881741
Cell Mol Life Sci. 2017 Jun;74(11):1985-1997
pubmed: 28154894
Aging (Albany NY). 2013 Jul;5(7):515-30
pubmed: 24018842
Hypertension. 2002 Oct;40(4):511-5
pubmed: 12364355
J Cell Sci. 2011 Jun 1;124(Pt 11):1936-42
pubmed: 21558418
Circ Res. 2003 Nov 14;93(10):e136-42
pubmed: 14563712
Biophys J. 2005 Jul;89(1):724-33
pubmed: 15879479
Int J Nanomedicine. 2013;8:2757-67
pubmed: 23946648
Biochem Biophys Res Commun. 2007 Mar 30;355(1):228-33
pubmed: 17291452
Circ Res. 2000 Jul 7;87(1):26-32
pubmed: 10884368
Wiley Interdiscip Rev Syst Biol Med. 2013 May-Jun;5(3):381-90
pubmed: 23401243
J Clin Invest. 2015 Nov 2;125(11):4223-38
pubmed: 26485286
Biophys J. 2015 Aug 18;109(4):687-98
pubmed: 26287621
Cardiovasc Res. 2005 May 1;66(2):187-9
pubmed: 15820186
Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H363-72
pubmed: 24285115
Annu Rev Cell Dev Biol. 2005;21:247-69
pubmed: 16212495
FASEB J. 2013 Sep;27(9):3652-9
pubmed: 23729588
Acta Anaesthesiol Scand. 2012 Mar;56(3):316-22
pubmed: 22150439
Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1541-7
pubmed: 12855481
Free Radic Biol Med. 2009 Sep 1;47(5):600-7
pubmed: 19500664
Shock. 2010 Aug;34(2):133-9
pubmed: 20634656
Am J Physiol Renal Physiol. 2015 May 1;308(9):F956-66
pubmed: 25673809
Nat Rev Mol Cell Biol. 2010 Apr;11(4):276-87
pubmed: 20308985
Circ Res. 2014 Mar 14;114(6):1052-68
pubmed: 24625729
J Cell Sci. 2015 Jul 1;128(13):2221-30
pubmed: 26092932
Science. 2009 Nov 27;326(5957):1208-12
pubmed: 19965462
Hypertension. 2014 Aug;64(2):391-6
pubmed: 24866143
Matrix Biol. 2017 Jan;57-58:366-373
pubmed: 27435904
Pflugers Arch. 2013 Oct;465(10):1451-8
pubmed: 23665954
Biochemistry. 2006 Feb 21;45(7):2200-10
pubmed: 16475808
Circ Res. 2007 Mar 16;100(5):633-44
pubmed: 17363709
Biophys J. 1995 Dec;69(6):2710-9
pubmed: 8599677
Kidney Int. 2012 Feb;81(4):407-11
pubmed: 22048126
Trends Cell Biol. 2012 Oct;22(10):536-45
pubmed: 22871642
Thromb Haemost. 2014 Jul 3;112(1):183-95
pubmed: 24573382
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15440-4
pubmed: 17032760
PLoS One. 2012;7(1):e29972
pubmed: 22253842
Science. 2013 Aug 30;341(6149):1240104
pubmed: 23990565
Cardiovasc Res. 2010 Jul 15;87(2):300-10
pubmed: 20462866
Mediators Inflamm. 2014;2014:694312
pubmed: 24803742
J Hypertens. 2015 Dec;33(12):2455-62
pubmed: 26378680
Biophys J. 2005 Jan;88(1):670-9
pubmed: 15489304
J Nutr. 2009 Mar;139(3):447-51
pubmed: 19176751
Pflugers Arch. 2012 Mar;463(3):487-96
pubmed: 22160395
Br J Clin Pharmacol. 2015 Sep;80(3):389-402
pubmed: 25778676
Sci Transl Med. 2011 Dec 7;3(112):112ra122
pubmed: 22158860
Eur J Cell Biol. 2013 Oct-Nov;92(10-11):339-48
pubmed: 24252517
Sci Rep. 2017 Apr 13;7:46476
pubmed: 28406245
Annu Rev Biomed Eng. 2007;9:121-67
pubmed: 17373886
Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1282-91
pubmed: 12234777
Neuron. 2015 Sep 23;87(6):1162-1179
pubmed: 26402601
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4651-5
pubmed: 1675786
Cell Physiol Biochem. 2007;20(5):255-68
pubmed: 17762155
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16281-6
pubmed: 17911245
J Biomech. 2014 Nov 28;47(15):3650-6
pubmed: 25446265
Nat Rev Mol Cell Biol. 2009 Jan;10(1):34-43
pubmed: 19197330
Curr Opin Lipidol. 2008 Oct;19(5):513-8
pubmed: 18769233
J Biol Chem. 2010 Nov 12;285(46):35479-87
pubmed: 20826796
Am J Physiol Cell Physiol. 2016 Dec 1;311(6):C846-C853
pubmed: 27681180
J Cell Biol. 2014 Oct 13;207(1):107-21
pubmed: 25313407
Circ Res. 2011 Apr 1;108(7):797-807
pubmed: 21330600
Nature. 2013 Apr 25;496(7446):518-22
pubmed: 23467095
Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):35-42
pubmed: 10634798
FASEB J. 2014 Sep;28(9):4015-25
pubmed: 24868010
PLoS One. 2013 Apr 23;8(4):e61377
pubmed: 23626676
Blood. 2011 Aug 11;118(6):1632-40
pubmed: 21652678
Nat Rev Nephrol. 2014 Mar;10(3):146-57
pubmed: 24419567
Antioxid Redox Signal. 2014 Feb 20;20(6):887-98
pubmed: 23682993
PLoS One. 2012;7(7):e41520
pubmed: 22844486
Free Radic Biol Med. 2010 Sep 1;49(5):687-706
pubmed: 20444433
Cell Motil Cytoskeleton. 2005 Oct;62(2):124-32
pubmed: 16145686
J Physiol. 2014 Mar 15;592(6):1175-6
pubmed: 24634017
Microvasc Res. 2010 Dec;80(3):394-401
pubmed: 20600162
J Autoimmun. 2016 Feb;67:90-101
pubmed: 26584738
Pflugers Arch. 2010 Oct;460(5):915-23
pubmed: 20809399