An ancient remedial repurposing: synthesis of new pinocembrin fatty acid acyl derivatives as potential antimicrobial/anti-inflammatory agents.
Animals
Anti-Bacterial Agents
/ chemical synthesis
Anti-Infective Agents
/ chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal
/ chemical synthesis
Antioxidants
/ chemical synthesis
Drug Evaluation, Preclinical
/ methods
Drug Repositioning
Fatty Acids
/ chemistry
Flavanones
/ chemistry
Glycyrrhiza
/ chemistry
Mice
Microbial Sensitivity Tests
Plant Extracts
/ pharmacology
RAW 264.7 Cells
Staphylococcus aureus
/ drug effects
Structure-Activity Relationship
Pinocembrin derivatives
anti-inflammatory activity
bacterial resistance
Journal
Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
pubmed:
22
2
2018
medline:
14
5
2019
entrez:
22
2
2018
Statut:
ppublish
Résumé
Five new pinocembrin derivatives (MC1-MC5) were synthesized by Steglich reaction, and investigated for their antimicrobial, antioxidant, and anti-inflammatory activity. MC2 (oleoyl derivative) and MC3 (linoleoyl derivative) have shown the highest inhibitory effects on bacterial proliferation, with MIC values of 32 μg/mL against Staphylococcus aureus. The docosahexaenoyl derivative MC5 displayed the highest anti-inflammatory activity, decreasing NO production in LPS-stimulated macrophages with an IC
Identifiants
pubmed: 29463111
doi: 10.1080/14786419.2018.1440224
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Anti-Inflammatory Agents, Non-Steroidal
0
Antioxidants
0
Fatty Acids
0
Flavanones
0
Plant Extracts
0
pinocembrin
8T7C8CH791
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM