Long non-coding RNAs: A crucial part of the vasculature puzzle.
Animals
Arteries
/ metabolism
Atherosclerosis
/ genetics
Cell Differentiation
Cellular Senescence
Endothelial Cells
/ metabolism
Gene Expression Regulation
Humans
Muscle, Smooth, Vascular
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
Neovascularization, Physiologic
Plaque, Atherosclerotic
RNA, Long Noncoding
/ genetics
Signal Transduction
Atherosclerosis
Endothelial cells
LncRNAs
Senescence
Smooth muscle cells
Journal
Vascular pharmacology
ISSN: 1879-3649
Titre abrégé: Vascul Pharmacol
Pays: United States
ID NLM: 101130615
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
11
01
2018
revised:
19
02
2018
accepted:
21
02
2018
pubmed:
27
2
2018
medline:
29
5
2019
entrez:
27
2
2018
Statut:
ppublish
Résumé
With the advent of empowering sequencing techniques over the past two decades, the scientific community has uncovered many underlying secrets of our genome. Non-coding transcripts covering a staggering 98% of our genome strongly suggest their involvement in diverse cellular pathways. A special class of non-coding RNAs (ncRNAs) namely long non-coding RNAs (lncRNAs) has garnered tremendous attention considering its implications in multiple developmental and pathophysiological processes. Accumulating evidence has established lncRNAs as robust regulators of pathways ranging from embryonic cell development to ultimate diseased phenotype. Here, in particular, we summarize the lncRNAs actively participating in the development of our vasculature and the ones which function as drivers or modulators of fatal vascular diseases.
Identifiants
pubmed: 29481972
pii: S1537-1891(18)30010-7
doi: 10.1016/j.vph.2018.02.008
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-138Informations de copyright
Copyright © 2018. Published by Elsevier Inc.