Evaluation of multikinase inhibitor LDN193189 induced hepatotoxicity in teleost fish

Animals Antineoplastic Agents / administration & dosage Antioxidants / metabolism Chemical and Drug Induced Liver Injury / etiology Dose-Response Relationship, Drug Female Lethal Dose 50 Liver / drug effects Male Poecilia Pyrazoles / administration & dosage Pyrimidines / administration & dosage
CYP450 LDN193189 Poecilia latipinna antioxidant cholestatic hepatitis hepatotoxicity histopathological alteration index

Journal

Drug and chemical toxicology
ISSN: 1525-6014
Titre abrégé: Drug Chem Toxicol
Pays: United States
ID NLM: 7801723

Informations de publication

Date de publication:
Nov 2019
Historique:
pubmed: 3 3 2018
medline: 22 7 2020
entrez: 3 3 2018
Statut: ppublish

Résumé

Currently, scientists show keen interest in the drugs that inhibit multiple kinases, LDN193189, being an example. It combats certain cancers

Identifiants

DOI: 10.1080/01480545.2018.1441865 PMID: 29498548
pubmed: 29498548
doi: 10.1080/01480545.2018.1441865
doi:

Substances chimiques

Antineoplastic Agents 0
Antioxidants 0
LDN 193189 0
Pyrazoles 0
Pyrimidines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

565-576

Auteurs

Isha Ranadive (I)

Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, India.
ORCID: 0000-0001-8885-7911

Sonam Patel (S)

Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, India.
ORCID: 0000-0002-0705-316X

Abhilasha Mhaske (A)

Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, India.

Gowri Kumari Uggini (GK)

Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, India.
ORCID: 0000-0002-7425-3268

Isha Desai (I)

Department of Biological Sciences, N. V. Patel College of Pure and Applied Sciences, Vallabh Vidhya Nagar, Anand, India.
ORCID: 0000-0003-1578-3127

Suresh Balakrishnan (S)

Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, India.
ORCID: 0000-0002-6559-022X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Dose létale 50 › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Système digestif › Foie › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Smegmamorpha › Cyprinodontiformes › Poecilia › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Evaluation of multikinase inhibitor LDN193189...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Evaluation of multikinase inhibitor LDN193189...