Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort.
Polygenic risk score
schizophrenia
season of birth
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
5
3
2018
medline:
6
8
2020
entrez:
5
3
2018
Statut:
ppublish
Résumé
There is strong evidence that people born in winter and in spring have a small increased risk of schizophrenia. As this 'season of birth' effect underpins some of the most influential hypotheses concerning potentially modifiable risk exposures, it is important to exclude other possible explanations for the phenomenon. Here we sought to determine whether the season of birth effect reflects gene-environment confounding rather than a pathogenic process indexing environmental exposure. We directly measured, in 136 538 participants from the UK Biobank (UKBB), the burdens of common schizophrenia risk alleles and of copy number variants known to increase the risk for the disorder, and tested whether these were correlated with a season of birth. Neither genetic measure was associated with season or month of birth within the UKBB sample. As our study was highly powered to detect small effects, we conclude that the season of birth effect in schizophrenia reflects a true pathogenic effect of environmental exposure.
Sections du résumé
BACKGROUND
There is strong evidence that people born in winter and in spring have a small increased risk of schizophrenia. As this 'season of birth' effect underpins some of the most influential hypotheses concerning potentially modifiable risk exposures, it is important to exclude other possible explanations for the phenomenon.
METHODS
Here we sought to determine whether the season of birth effect reflects gene-environment confounding rather than a pathogenic process indexing environmental exposure. We directly measured, in 136 538 participants from the UK Biobank (UKBB), the burdens of common schizophrenia risk alleles and of copy number variants known to increase the risk for the disorder, and tested whether these were correlated with a season of birth.
RESULTS
Neither genetic measure was associated with season or month of birth within the UKBB sample.
CONCLUSIONS
As our study was highly powered to detect small effects, we conclude that the season of birth effect in schizophrenia reflects a true pathogenic effect of environmental exposure.
Identifiants
pubmed: 29501066
pii: S0033291718000454
doi: 10.1017/S0033291718000454
pmc: PMC7610956
mid: EMS126976
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2499-2504Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : British Heart Foundation
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201171
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0800509
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P005748/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201171/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Références
Am J Med Genet. 2000 Spring;97(1):12-7
pubmed: 10813800
Sleep. 2009 Mar;32(3):423-6
pubmed: 19294963
Neurosci Biobehav Rev. 2017 Apr;75:361-377
pubmed: 28188887
Genome Res. 2013 Sep;23(9):1395-409
pubmed: 23657883
Nat Genet. 2012 Jul 22;44(8):955-9
pubmed: 22820512
Arch Gen Psychiatry. 2003 Dec;60(12):1187-92
pubmed: 14662550
Schizophr Res. 2007 Jul;93(1-3):229-36
pubmed: 17475446
Br J Psychiatry. 2014 Feb;204(2):108-14
pubmed: 24311552
Nat Genet. 2014 Oct;46(10):1063-71
pubmed: 25217958
Nat Methods. 2013 Jan;10(1):5-6
pubmed: 23269371
Schizophr Bull. 1986;12(2):173-86
pubmed: 3520803
Schizophr Res. 1999 Dec 21;40(3):173-7
pubmed: 10638855
Nat Genet. 2013 Oct;45(10):1150-9
pubmed: 23974872
Psychol Bull. 1985 Nov;98(3):569-94
pubmed: 4080898
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Mol Psychiatry. 2018 May;23(5):1287-1292
pubmed: 28115737
N Engl J Med. 1999 Feb 25;340(8):603-8
pubmed: 10029644
PLoS Genet. 2013 Mar;9(3):e1003348
pubmed: 23555274
Br J Psychiatry. 1988 Apr;152:460-5
pubmed: 3167394
PLoS One. 2015 Jun 15;10(6):e0128856
pubmed: 26076384
Nature. 2014 Feb 13;506(7487):185-90
pubmed: 24463508
Biol Psychiatry. 2009 Oct 15;66(8):722-7
pubmed: 19596120
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Nat Neurosci. 2016 Apr;19(4):571-7
pubmed: 26974950
PLoS One. 2012;7(4):e34866
pubmed: 22496872
Mol Psychiatry. 2014 Nov;19(11):1201-4
pubmed: 24957864
Schizophr Bull. 2003;29(3):587-93
pubmed: 14609251
Mol Psychiatry. 2016 Jun;21(6):749-57
pubmed: 27067015
Arch Gen Psychiatry. 1977 Sep;34(9):1065-70
pubmed: 901136
Nat Genet. 2018 Mar;50(3):381-389
pubmed: 29483656
J Clin Psychiatry. 2015 Feb;76(2):128-34
pubmed: 25562672
Biol Psychiatry. 2017 Jul 15;82(2):103-110
pubmed: 27773354
BMJ Open. 2017 Feb 17;7(2):e012406
pubmed: 28213594
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Biometrics. 1999 Dec;55(4):997-1004
pubmed: 11315092
Scand J Public Health. 2012 Feb;40(1):43-50
pubmed: 21930618
Neurosci Lett. 1999 Oct 22;274(2):139-41
pubmed: 10553957
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Schizophr Res. 2004 Jan 1;66(1):1-6
pubmed: 14693347
Br J Psychiatry. 1996 Feb;168(2):205-9
pubmed: 8837911