Multifaceted immune functions of human defensins and underlying mechanisms.
Defensins
Immune functions
Pathways
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
17
01
2018
accepted:
26
02
2018
pubmed:
5
3
2018
medline:
7
3
2020
entrez:
5
3
2018
Statut:
ppublish
Résumé
Defensins have been long recognized as natural antimicrobial peptides, but they also possess diverse and versatile immune functions. Defensins can both induce inflammation and suppress inflammatory responses by acting on specific cells through distinct mechanisms. Defensins can also modulate the immune response by forming a complex with cellular molecules including proteins, nucleic acids, and carbohydrates. The mechanisms of defensin-mediated immune modulation appear to be cell-type and context specific. Because the levels of human defensins are often altered in response to infection or disease states, suggesting their clinical relevance, this review summarizes the complex immune functions of human defensins and their underlying mechanisms of action, which have implications for the development of new therapeutics.
Identifiants
pubmed: 29501617
pii: S1084-9521(17)30415-9
doi: 10.1016/j.semcdb.2018.02.023
pmc: PMC6485945
mid: NIHMS1524078
pii:
doi:
Substances chimiques
CCR6 protein, human
0
Interleukins
0
Receptors, CCR6
0
Toll-Like Receptors
0
alpha-Defensins
0
beta-Defensins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
163-172Subventions
Organisme : NIAID NIH HHS
ID : R01 AI081559
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136948
Pays : United States
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
J Biol Chem. 2008 May 30;283(22):15309-18
pubmed: 18362142
Immunobiology. 2012 Apr;217(4):436-45
pubmed: 22137028
Nat Rev Immunol. 2003 Sep;3(9):710-20
pubmed: 12949495
J Immunol. 2007 Jul 15;179(2):984-92
pubmed: 17617590
J Leukoc Biol. 2000 Jul;68(1):9-14
pubmed: 10914484
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44
pubmed: 20679225
Nature. 2007 Oct 4;449(7162):564-9
pubmed: 17873860
J Leukoc Biol. 2013 Sep;94(3):459-71
pubmed: 23804808
J Cell Biochem. 2008 Aug 15;104(6):2286-97
pubmed: 18449938
Front Immunol. 2012 Oct 08;3:294
pubmed: 23060878
Annu Rev Immunol. 2004;22:181-215
pubmed: 15032578
J Biol Chem. 1996 Feb 9;271(6):2935-40
pubmed: 8621683
J Invest Dermatol. 2005 May;124(5):931-8
pubmed: 15854033
Infect Immun. 1987 Mar;55(3):568-71
pubmed: 3643886
J Immunol. 2009 Aug 1;183(3):2122-32
pubmed: 19596979
J Immunol. 2006 Jul 15;177(2):782-6
pubmed: 16818731
PLoS One. 2010 Jun 08;5(6):e10993
pubmed: 20544025
AIDS. 2003 Sep 26;17(14):F23-32
pubmed: 14502030
J Leukoc Biol. 2012 Nov;92(5):1083-91
pubmed: 22837529
J Immunol. 2007 Nov 15;179(10):6504-13
pubmed: 17982039
J Immunol. 2004 Sep 1;173(5):3482-91
pubmed: 15322213
J Infect Dis. 2007 Sep 15;196(6):835-43
pubmed: 17703413
J Biol Chem. 1992 Nov 15;267(32):23216-25
pubmed: 1429669
FEMS Immunol Med Microbiol. 2003 Aug 18;38(1):59-64
pubmed: 12900056
Gut. 2004 Nov;53(11):1658-64
pubmed: 15479689
Int J Mol Med. 2010 Dec;26(6):925-34
pubmed: 21042789
Int J Mol Med. 2015 Jun;35(6):1603-9
pubmed: 25816245
J Dent Res. 2008 Jul;87(7):682-6
pubmed: 18573991
Eur J Immunol. 2007 Sep;37(9):2474-86
pubmed: 17705135
Int Immunol. 2002 Apr;14(4):421-6
pubmed: 11934878
Immunobiology. 2016 Nov;221(11):1259-65
pubmed: 27377709
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4350-5
pubmed: 27044108
Trends Immunol. 2002 Jun;23(6):291-6
pubmed: 12072367
J Immunol. 2010 Mar 24;184(9):5263-5270
pubmed: 20335534
AIDS. 2004 May 21;18(8):1217-8
pubmed: 15166542
J Immunol. 2007 Jul 15;179(2):1245-53
pubmed: 17617617
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33
pubmed: 11854508
J Immunol. 2002 Sep 1;169(5):2516-23
pubmed: 12193721
Cell Mol Life Sci. 2006 Jun;63(11):1294-313
pubmed: 16710608
Carcinogenesis. 2011 Feb;32(2):168-74
pubmed: 21071608
Eur J Immunol. 2011 Nov;41(11):3291-300
pubmed: 21809339
Retrovirology. 2011 Jun 14;8:45
pubmed: 21672195
Blood. 2012 Nov 1;120(18):3699-707
pubmed: 22927244
Immunology. 2011 Oct;134(2):151-60
pubmed: 21896010
Antimicrob Agents Chemother. 2003 Aug;47(8):2666-8
pubmed: 12878538
Eur J Immunol. 2017 Apr;47(4):658-664
pubmed: 28102569
PLoS Pathog. 2017 Jun 16;13(6):e1006446
pubmed: 28622386
Eur J Immunol. 2015 Jan;45(1):203-13
pubmed: 25332209
FEMS Immunol Med Microbiol. 2007 Oct;51(1):171-84
pubmed: 17645739
Immunology. 2004 Mar;111(3):273-81
pubmed: 15009427
J Biol Chem. 2005 Mar 4;280(9):8260-5
pubmed: 15613481
J Immunol. 2013 Jul 15;191(2):865-74
pubmed: 23776172
Int J Gynaecol Obstet. 2008 Oct;103(1):50-4
pubmed: 18635180
Microbes Infect. 2005 Jul;7(9-10):1117-27
pubmed: 15893496
J Clin Invest. 1985 Oct;76(4):1427-35
pubmed: 2997278
Science. 1999 Oct 15;286(5439):525-8
pubmed: 10521347
Mol Immunol. 2007 Jul;44(14):3608-14
pubmed: 17448537
PLoS One. 2012;7(2):e31712
pubmed: 22359618
EMBO Mol Med. 2013 Oct;5(10):1465-83
pubmed: 24039130
Regul Pept. 1996 Apr 9;62(1):13-21
pubmed: 8738877
Inflamm Bowel Dis. 2016 May;22(5):1119-28
pubmed: 26891258
Exp Dermatol. 2003 Dec;12(6):755-60
pubmed: 14714554
J Acquir Immune Defic Syndr. 2004 Aug 15;36(5):993-1005
pubmed: 15247551
J Clin Invest. 2005 Mar;115(3):765-73
pubmed: 15719067
Am J Physiol. 1997 May;272(5 Pt 1):L888-96
pubmed: 9176253
Sci Transl Med. 2011 Mar 9;3(73):73ra19
pubmed: 21389263
Nat Rev Immunol. 2018 Feb;18(2):134-147
pubmed: 28990587
J Immunol. 2011 Feb 1;186(3):1411-20
pubmed: 21178014
J Mol Biol. 2013 Nov 15;425(22):4479-95
pubmed: 23938203
J Immunol. 2007 Sep 1;179(5):3109-18
pubmed: 17709525
Science. 2002 Nov 1;298(5595):1025-9
pubmed: 12411706
J Immunol. 2007 Sep 15;179(6):3958-65
pubmed: 17785833
J Cell Physiol. 2008 Mar;214(3):820-7
pubmed: 17786963
Oral Oncol. 2009 Aug;45(8):696-702
pubmed: 19097930
FEBS Lett. 2007 Feb 6;581(3):515-20
pubmed: 17250830
J Immunol. 2005 Jan 15;174(2):992-1002
pubmed: 15634923
AIDS. 2003 Nov 7;17(16):F39-48
pubmed: 14571200
Nat Immunol. 2005 Jun;6(6):551-7
pubmed: 15908936
J Immunol. 2015 Nov 1;195(9):4438-45
pubmed: 26416278
J Exp Med. 2009 Aug 31;206(9):1983-94
pubmed: 19703986
PLoS Genet. 2015 Dec 08;11(12):e1005673
pubmed: 26646717
Curr Drug Targets Inflamm Allergy. 2003 Sep;2(3):224-31
pubmed: 14561157
J Leukoc Biol. 2009 Oct;86(4):941-8
pubmed: 19477909
Crit Rev Immunol. 2008;28(3):185-200
pubmed: 19024344
J Immunol. 2010 Jun 15;184(12):6688-94
pubmed: 20483750
J Immunol. 2008 May 1;180(9):6176-85
pubmed: 18424739
Cell Immunol. 2015 Oct;297(2):61-8
pubmed: 26302933
J Biol Chem. 2000 Oct 20;275(42):32911-8
pubmed: 10906336
Eur J Immunol. 2010 Apr;40(4):1073-8
pubmed: 20104491
Trends Immunol. 2009 Nov;30(11):531-7
pubmed: 19699678
J Exp Med. 2006 Oct 2;203(10):2271-9
pubmed: 16982811
Cancer Res. 2004 Mar 1;64(5):1861-6
pubmed: 14996750
J Immunol. 2007 Jun 15;178(12):8046-52
pubmed: 17548642
Int Immunol. 2008 Apr;20(4):543-53
pubmed: 18308714
J Clin Invest. 1989 Dec;84(6):2017-20
pubmed: 2592571
Clin Exp Allergy. 2017 Sep;47(9):1138-1149
pubmed: 28437599
Blood. 2000 Aug 15;96(4):1393-8
pubmed: 10942383
J Periodontal Res. 2005 Dec;40(6):474-81
pubmed: 16302926
Biochem Pharmacol. 1988 Mar 1;37(5):951-6
pubmed: 3345204
Antimicrob Agents Chemother. 2006 Apr;50(4):1433-41
pubmed: 16569862
Immunol Rev. 2012 Jan;245(1):84-112
pubmed: 22168415
BMC Cancer. 2010 Oct 27;10:588
pubmed: 20979654
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18631-5
pubmed: 18006661
J Biol Chem. 1989 Jul 5;264(19):11200-3
pubmed: 2500436
Crit Rev Immunol. 2006;26(6):545-76
pubmed: 17341194
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8880-5
pubmed: 12840147
J Immunol. 2005 Apr 15;174(8):4870-9
pubmed: 15814714
Semin Immunol. 2007 Apr;19(2):70-83
pubmed: 17485224
Cytokine. 2016 Jul;83:53-60
pubmed: 27031443
J Biol Chem. 1996 Jul 26;271(30):17650-5
pubmed: 8663495
J Leukoc Biol. 2011 Aug;90(2):343-56
pubmed: 21551252
Protein Sci. 2006 Dec;15(12):2749-60
pubmed: 17088326
Infect Immun. 2005 Aug;73(8):4823-33
pubmed: 16040996
Nat Rev Immunol. 2006 Jun;6(6):447-56
pubmed: 16724099
J Biol Chem. 2014 Aug 15;289(33):22969-79
pubmed: 24970887
Blood. 2002 Dec 1;100(12):4026-32
pubmed: 12393692
J Immunol. 2013 Jul 1;191(1):345-52
pubmed: 23698749
Blood. 1998 Nov 15;92(10):3898-903
pubmed: 9808583
Innate Immun. 2014 Apr;20(3):290-300
pubmed: 23792296
Blood. 2006 Apr 1;107(7):2936-42
pubmed: 16322472