Limiting angiogenesis to modulate scar formation.
Angiogenesis
Cartilage
Cornea
Embryonic vascularisation
Fetal
Fibrotic response
Scar-free healing
Scarring
Tendon
VEGF
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
23
11
2017
revised:
22
01
2018
accepted:
26
02
2018
pubmed:
5
3
2018
medline:
30
7
2020
entrez:
5
3
2018
Statut:
ppublish
Résumé
Angiogenesis, the process of new blood vessel formation from existing blood vessels, is a key aspect of virtually every repair process. During wound healing an extensive, but immature and leaky vascular plexus forms which is subsequently reduced by regression of non-functional vessels. More recent studies indicate that uncontrolled vessel growth or impaired vessel regression as a consequence of an excessive inflammatory response can impair wound healing, resulting in scarring and dysfunction. However, in order to elucidate targetable factors to promote functional tissue regeneration we need to understand the molecular and cellular underpinnings of physiological angiogenesis, ranging from induction to resolution of blood vessels. Especially for avascular tissues (e.g. cornea, tendon, ligament, cartilage, etc.), limiting rather than boosting vessel growth during wound repair potentially is beneficial to restore full tissue function and may result in favourable long-term healing outcomes.
Identifiants
pubmed: 29501628
pii: S0169-409X(18)30038-3
doi: 10.1016/j.addr.2018.02.010
pii:
doi:
Substances chimiques
Protein Kinase Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
170-189Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.