Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study.
Adolescent
Adult
Biomarkers
/ blood
Bone Remodeling
/ physiology
Cancer Survivors
/ statistics & numerical data
Child
Diet Surveys
Female
Humans
Male
Nutritional Status
/ physiology
Parathyroid Hormone
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ blood
Surveys and Questionnaires
Vitamin D
/ blood
Young Adult
25-Hydroxyvitamin D(3)
Acute lymphoblastic leukemia
Bone formation
Bone resorption
CTX
P1NP
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
23
10
2017
revised:
29
12
2017
accepted:
03
02
2018
pubmed:
6
3
2018
medline:
21
4
2020
entrez:
6
3
2018
Statut:
ppublish
Résumé
The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44-2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5-97.5 The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations.
Sections du résumé
BACKGROUND
The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood.
OBJECTIVE
This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors.
RESULTS
Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44-2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5-97.5
CONCLUSION
The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations.
Identifiants
pubmed: 29503055
pii: S0261-5614(18)30069-4
doi: 10.1016/j.clnu.2018.02.006
pii:
doi:
Substances chimiques
Biomarkers
0
Parathyroid Hormone
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
912-919Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.