Strategies for the cure of HIV infection.
Estrategias de curación de la infección por VIH.
Curación funcional
Eradication
Erradicación
Functional cure
HIV
Latencia
Latency
Reservoirs
Reservorios
VIH
Journal
Enfermedades infecciosas y microbiologia clinica (English ed.)
ISSN: 2529-993X
Titre abrégé: Enferm Infecc Microbiol Clin (Engl Ed)
Pays: Spain
ID NLM: 101777541
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
01
08
2017
revised:
29
12
2017
accepted:
13
01
2018
pubmed:
8
3
2018
medline:
3
1
2020
entrez:
8
3
2018
Statut:
ppublish
Résumé
The disadvantages of the long-term administration of antiretroviral therapy as well as the huge number of affected persons have placed the cure of HIV as a primary goal of Public Health. HIV may persist in the organism by at least four mechanisms: a latently infected cellular reservoir, the persistent replication of HIV in spite of ART, anatomic sanctuaries, and the immune dysfunction. Several strategies directed against these mechanisms have been developed. With all this, a complete eradication of HIV has been achieved in a patient using the transplantation of haemopoietic stem cells that were resistant to HIV-infection, and there are examples of functional cure either spontaneously (elite controllers) or after antiretroviral therapy (post-treatment controllers). However, no strategies have been successful in reducing the reservoir size, nor in achieving constant, uniform remissions. The failure of isolated strategies makes it likely that the combination of several of them may be the future solution.
Identifiants
pubmed: 29510860
pii: S0213-005X(18)30011-9
doi: 10.1016/j.eimc.2018.01.007
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
265-273Informations de copyright
Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.