Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis.
CD3
FoxP3
IL17
feline
immunohistochemistry
uveitis
Journal
Veterinary ophthalmology
ISSN: 1463-5224
Titre abrégé: Vet Ophthalmol
Pays: England
ID NLM: 100887377
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
pubmed:
9
3
2018
medline:
19
3
2019
entrez:
9
3
2018
Statut:
ppublish
Résumé
To characterize the immune cells present in different forms of feline anterior uveitis. Eyes were obtained from 49 cats diagnosed with chronic idiopathic lymphoplasmacytic anterior uveitis, 7 cats with feline infectious peritonitis (FIP), and 9 cats euthanized for nonocular disease. H&E sections were scored on the level of infiltrate in the anterior uvea. Immunohistochemistry was performed for FoxP3, CD3, and IL-17A, and positive cells were quantified in multiple images of each sample. A generalized estimating equation tested for an association between the level of inflammation and the prevalence of these cell types. Cells stained positive for IL-17A in idiopathic uveitis but not in FIP samples. We found significantly fewer FoxP3 Idiopathic, but not FIP-associated, uveitis appears to have Th17 cell involvement. The numbers of FoxP3
Substances chimiques
Forkhead Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-212Subventions
Organisme : British Small Animal Veterinary Association
Organisme : MSD Animal Health
Organisme : Morris Animal Foundation
Informations de copyright
© 2018 American College of Veterinary Ophthalmologists.