Vitreous IL-8 and VEGF levels in diabetic macular edema with or without subretinal fluid.
Adult
Aged
Analysis of Variance
Case-Control Studies
Diabetic Retinopathy
/ metabolism
Female
Glycated Hemoglobin
/ analysis
Humans
Interleukin-8
/ metabolism
Macular Edema
/ metabolism
Male
Middle Aged
Prospective Studies
Retrospective Studies
Subretinal Fluid
/ physiology
Vascular Endothelial Growth Factor A
/ metabolism
Cystoid macular edema
Diabetes
Interleukin-8
Intraocular cytokines
Subretinal fluid
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
18
10
2017
accepted:
21
02
2018
pubmed:
11
3
2018
medline:
11
4
2019
entrez:
11
3
2018
Statut:
ppublish
Résumé
To determine the cytokine levels in vitreous samples of diabetic macular edema (DME) patients in comparison with nondiabetic patients, and to evaluate the effect of subretinal fluid on the cytokine levels of vitreous samples. In this prospective case-control study, 11 eyes of 11 patients with DME and subretinal fluid, 11 eyes of 11 patients with DME without subretinal fluid, and 14 eyes of 14 patients who had undergone vitreoretinal surgery for the epiretinal membrane or a macular hole (control group) were evaluated. The blood glycated hemoglobin (HbA1c) level, vitreous vascular endothelial growth factor (VEGF), and interleukin-8 (IL-8) levels were determined. The vitreous VEGF level of patients in DME groups was significantly higher than the control group (p < 0.001) without significant difference between DME patients with and without subretinal fluid (p = 0.796). The vitreous IL-8 level of DME patients with subretinal fluid was significantly higher than both control (p = 0.002) and DME without subretinal fluid groups (p = 0.019). The blood HbA1c level was significantly higher in DME group with subretinal fluid than those without subretinal fluid (8.7 ± 1.32 and 7.1 ± 1.13%, respectively, p = 0.010). The only significant correlation was between vitreous VEGF level and blood HbA1c level in DME patients without subretinal fluid (r = 0.813, p = 0.002). IL-8 level in vitreous samples was higher in DME patients with subretinal fluid than those without subretinal fluid, suggesting that inflammation is an important factor in the progression of DME leading to the subretinal fluid formation in diabetic patients.
Identifiants
pubmed: 29524030
doi: 10.1007/s10792-018-0874-6
pii: 10.1007/s10792-018-0874-6
doi:
Substances chimiques
CXCL8 protein, human
0
Glycated Hemoglobin A
0
Interleukin-8
0
Vascular Endothelial Growth Factor A
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
821-828Subventions
Organisme : Kocaeli University Scientific Research Project Coordination
ID : 2014/83HD
Organisme : Kocaeli University Scientific Research Project Coordination
ID : 2015/50HD
Organisme : Kocaeli University Scientific Research Project Coordination
ID : 2014/84HD
Organisme : Kocaeli University Scientific Research Project Coordination
ID : 2015/49HD
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