Cutaneous squamous cell carcinomas are associated with basal proliferating actinic keratoses.
Aged
Aged, 80 and over
Cancer Care Facilities
/ statistics & numerical data
Carcinoma, Squamous Cell
/ epidemiology
Cell Proliferation
Epidermis
/ pathology
Female
Germany
/ epidemiology
Head
Head and Neck Neoplasms
/ epidemiology
Humans
Keratinocytes
/ pathology
Keratosis, Actinic
/ diagnosis
Male
Prevalence
Retrospective Studies
Severity of Illness Index
Skin Neoplasms
/ epidemiology
Journal
The British journal of dermatology
ISSN: 1365-2133
Titre abrégé: Br J Dermatol
Pays: England
ID NLM: 0004041
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
accepted:
01
03
2018
pubmed:
12
3
2018
medline:
6
5
2020
entrez:
12
3
2018
Statut:
ppublish
Résumé
In addition to the extent of atypical keratinocytes throughout the epidermis, actinic keratoses (AKs) are histologically characterized by downward-directed basal-layer expansion. It is not known whether this growth pattern correlates with the risk of developing invasive squamous cell carcinoma (iSCC). To characterize the prevalence of downward-directed basal-layer expansion of AKs adjacent to iSCC. The epidermis overlying and adjacent to iSCCs was assessed histologically. We determined the histological grade (AK I-III), basal growth pattern (PRO I-III) and accompanying parameters such as adnexal involvement. Among 307 lesions, 52·4% of AKs were histologically classified as AK grade I, 38·1% as AK II and 6·8% as AK III (χ Basal proliferative AKs, as well as atypical keratinocytes restricted to the lower third of the epidermis, are most commonly seen adjacent to iSCC, with less evidence for full-thickness epidermal dysplasia. Our study supports the important role of dysplastic keratinocytes in the epidermal basal layer and their potential association with iSCC.
Sections du résumé
BACKGROUND
In addition to the extent of atypical keratinocytes throughout the epidermis, actinic keratoses (AKs) are histologically characterized by downward-directed basal-layer expansion. It is not known whether this growth pattern correlates with the risk of developing invasive squamous cell carcinoma (iSCC).
OBJECTIVES
To characterize the prevalence of downward-directed basal-layer expansion of AKs adjacent to iSCC.
METHODS
The epidermis overlying and adjacent to iSCCs was assessed histologically. We determined the histological grade (AK I-III), basal growth pattern (PRO I-III) and accompanying parameters such as adnexal involvement.
RESULTS
Among 307 lesions, 52·4% of AKs were histologically classified as AK grade I, 38·1% as AK II and 6·8% as AK III (χ
CONCLUSIONS
Basal proliferative AKs, as well as atypical keratinocytes restricted to the lower third of the epidermis, are most commonly seen adjacent to iSCC, with less evidence for full-thickness epidermal dysplasia. Our study supports the important role of dysplastic keratinocytes in the epidermal basal layer and their potential association with iSCC.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
916-921Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 British Association of Dermatologists.