Vascular fibrinoid necrosis in the urinary bladder of ketamine abusers: A new finding that may provide a clue to the pathogenesis of ketamine-induced vesicopathy.
Arthus reaction
Masson trichrome staining
fibrinoid necrosis
immune complex-mediated vasculitis
ketamine-induced vesicopathy
Journal
Lower urinary tract symptoms
ISSN: 1757-5672
Titre abrégé: Low Urin Tract Symptoms
Pays: Australia
ID NLM: 101506777
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
15
11
2017
revised:
07
01
2018
accepted:
05
02
2018
pubmed:
13
3
2018
medline:
18
12
2019
entrez:
13
3
2018
Statut:
ppublish
Résumé
Two 31-year-old women who had abused ketamine, 1 for 8 years and 1 for 5 years, presented with ketamine-induced vesicopathy with urinary frequency, decreased bladder capacity, and detrusor overactivity. An enterocystoplasty was performed in both cases. The pathology of the urinary bladders in both women showed ulcerative cystitis and fibrinoid necrosis of vessels; the latter was confirmed by Masson trichrome staining. Fibrinoid necrosis of vessels is a kind of immune complex-mediated vasculitis that induces the release of inflammatory mediators, with subsequent thrombosis, ischemic injury, and eventual tissue necrosis in localized areas, the so-called Arthus reaction. The new finding of fibrinoid necrosis in the urinary bladders of ketamine abusers may provide a new clue to the pathogenesis of ketamine-induced vesicopathy.
Substances chimiques
Ketamine
690G0D6V8H
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
O221-O223Informations de copyright
© 2018 John Wiley & Sons Australia, Ltd.