Enoxaparin pretreatment effect on local and systemic inflammation biomarkers in the animal burn model.
Animals
Anti-Inflammatory Agents
/ pharmacology
Anticoagulants
/ pharmacology
Antithrombin III
/ metabolism
Biomarkers
/ metabolism
Burns
/ drug therapy
C-Reactive Protein
/ metabolism
Disease Models, Animal
Edema
/ drug therapy
Enoxaparin
/ pharmacology
Heparin, Low-Molecular-Weight
/ pharmacology
Inflammation
/ drug therapy
Male
Peptide Hydrolases
/ metabolism
Rats
Rats, Sprague-Dawley
Burn
Coagulation
Enoxaparin
Inflammatory markers
Oedema
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
08
11
2017
accepted:
22
01
2018
pubmed:
20
3
2018
medline:
28
11
2019
entrez:
18
3
2018
Statut:
ppublish
Résumé
Low-molecular weight heparins (LMWH) are anticoagulants that have shown anti-inflammatory activity in several experimental models. Hot water burn inflammatory model accurately simulates human clinical situations allowing its use for nociception test and evaluation of anti-inflammatory drugs. The present study aims to evaluate the enoxaparin pretreatment on local and systemic inflammation biomarkers in the animal burn model. Inflammation was induced by submersing the rat left hind paw in water at 60
Identifiants
pubmed: 29549537
doi: 10.1007/s10787-018-0444-6
pii: 10.1007/s10787-018-0444-6
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Anticoagulants
0
Biomarkers
0
Enoxaparin
0
Heparin, Low-Molecular-Weight
0
antithrombin III-protease complex
0
Antithrombin III
9000-94-6
C-Reactive Protein
9007-41-4
Peptide Hydrolases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
521-529Références
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