Parental Depressive Symptoms Potentiate the Effect of Youth Negative Mood Symptoms on Gene Expression in Children with Asthma.
Adolescent
Affective Symptoms
/ epidemiology
Asthma
/ epidemiology
Child
Child of Impaired Parents
/ statistics & numerical data
Comorbidity
Depression
/ epidemiology
Female
Gene Expression
/ genetics
Humans
Longitudinal Studies
Male
Parents
Receptors, Adrenergic, beta-2
/ genetics
Receptors, Glucocorticoid
/ genetics
Asthma
Depression
Molecular genetics
Parents-child relationships
Journal
Journal of abnormal child psychology
ISSN: 1573-2835
Titre abrégé: J Abnorm Child Psychol
Pays: United States
ID NLM: 0364547
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
21
3
2018
medline:
31
3
2020
entrez:
21
3
2018
Statut:
ppublish
Résumé
Depressive symptoms in parents and in youths have been found to relate to disease comorbidity processes in children, including greater disease-related impairment and poorer clinical outcomes. The current study sought to assess whether coming from a family characterized by more depressive symptoms on average would potentiate the effects of changes in youths' own negative mood on the expression of two receptor genes relevant to asthma that are the primary targets of asthma medication, such that the combination of low child negative mood in the context of greater parental depressive symptoms would relate to the lowest levels of gene expression. One-hundred-twenty youths with diagnosed asthma and their parents participated every 6 months for 2 years. Parents reported on their depressive symptoms, children reported negative mood symptoms, and youths completed blood draws from which expression of Glucocorticoid Receptor (GR) and Beta2 Adrenergic Receptor (β
Identifiants
pubmed: 29556870
doi: 10.1007/s10802-018-0420-z
pii: 10.1007/s10802-018-0420-z
pmc: PMC6148436
mid: NIHMS952890
doi:
Substances chimiques
Receptors, Adrenergic, beta-2
0
Receptors, Glucocorticoid
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-108Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL073975
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL108723
Pays : United States
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