Oxysterol species: reliable markers of oxidative stress in diabetes mellitus.
Diabetes mellitus
LC–MS/MS
Oxidative stress
Oxysterols
Tandem mass spectrometry
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
08
01
2018
accepted:
09
03
2018
pubmed:
23
3
2018
medline:
14
3
2019
entrez:
23
3
2018
Statut:
ppublish
Résumé
To assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM). In total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry and N,N-dimethylglycine derivatization. Correlations between oxysterols and clinical/biochemical characteristics of the diabetes patients, and factors affecting 7-Kchol and chol-triol, were also determined. Plasma 7-Kchol and chol-triol levels were significantly higher in type 1 and type 2 diabetes patients compared to healthy controls (P < 0.001). Significant positive correlations were observed between oxysterol levels and levels of glycated hemoglobin (HbA1c), glucose, serum total cholesterol, low-density lipoprotein, very-low-density lipoprotein, and triglycerides, as well as the number of coronary risk factors. Statins, oral hypoglycemic agents, and antihypertensive agents reduced the levels of oxysterols in type 2 diabetes patients. Statin use, HbA1c levels, and the number of coronary risk factors accounted for 98.8% of the changes in 7-Kchol levels, and total cholesterol, smoking status, and the number of coronary risk factors accounted for 77.3% of the changes in chol-triol levels in type 2 diabetes patients. Plasma oxysterol levels in DM, and particularly type 2 DM, may yield complementary information regarding oxidative stress for the clinical follow-up of diabetes patients, especially those with coronary risk factors.
Identifiants
pubmed: 29564756
doi: 10.1007/s40618-018-0873-5
pii: 10.1007/s40618-018-0873-5
doi:
Substances chimiques
Biomarkers
0
Oxysterols
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-17Subventions
Organisme : Hacettepe University Scientific Research Projects Coordination Unit
ID : THD-201610908
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