Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration.

Animals Annulus Fibrosus / drug effects Biocompatible Materials / pharmacology Cattle Cell Movement / drug effects Cells, Cultured Chemokine CCL5 / pharmacology Disease Models, Animal Drug Delivery Systems / methods Fibrin / administration & dosage Gels Intervertebral Disc / drug effects Organ Culture Techniques Pilot Projects Receptors, CCR5 / drug effects Regeneration / drug effects Sheep
annulus fibrosus bovine caudal disc organ culture chemokine (C-C motif) ligand 5 chemotactic effect sheep animal study

Journal

Cartilage
ISSN: 1947-6043
Titre abrégé: Cartilage
Pays: United States
ID NLM: 101518378

Informations de publication

Date de publication:
04 2020
Historique:
pubmed: 28 3 2018
medline: 12 6 2021
entrez: 28 3 2018
Statut: ppublish

Résumé

To explore if chemokine (C-C motif) ligand 5 (CCL5) delivery could recruit annulus fibrosus (AF) cells to the injury sites and facilitate the repair of ruptured AF. The effects of CCL5 on bovine AF cells CCL5 showed a chemotactic effect on AF cells in a dose-dependent manner. AF cells cultured with CCL5 CCL5 has a chemotactic effect on AF cells

Identifiants

DOI: 10.1177/1947603518764263 PMID: 29582673 PMC: PMC7097979
pubmed: 29582673
doi: 10.1177/1947603518764263
pmc: PMC7097979
doi:

Substances chimiques

Biocompatible Materials 0
Chemokine CCL5 0
Gels 0
Receptors, CCR5 0
Fibrin 9001-31-4

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

169-180

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR057397
Pays : United States

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Auteurs

Zhiyu Zhou (Z)

Department of Orthopaedic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
AO Research Institute Davos, Davos, Switzerland.
Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Stephan Zeiter (S)

AO Research Institute Davos, Davos, Switzerland.
Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.
ORCID: 0000-0002-8155-4202

Tanja Schmid (T)

AO Research Institute Davos, Davos, Switzerland.
Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.

Daisuke Sakai (D)

Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.
Department of Orthopaedic Surgery, Surgical Science and Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

James C Iatridis (JC)

Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.
Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Guangqian Zhou (G)

Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine, Department of Medical Cell Biology and Genetics, Health Sciences Center, Shenzhen University, Shenzhen, China.

R Geoff Richards (RG)

AO Research Institute Davos, Davos, Switzerland.
Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.

Mauro Alini (M)

AO Research Institute Davos, Davos, Switzerland.
Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.

Sibylle Grad (S)

AO Research Institute Davos, Davos, Switzerland.
Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.

Zhen Li (Z)

AO Research Institute Davos, Davos, Switzerland.
Collaborative Research Partner Annulus Fibrosus Repair Program, AO Foundation, Davos, Switzerland.
Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine, Department of Medical Cell Biology and Genetics, Health Sciences Center, Shenzhen University, Shenzhen, China.
ORCID: 0000-0002-9754-6389

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Anneau fibreux › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux biocompatibles › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Cellules › Cellules cultivées › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CC › Chimiokine CCL5 › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Fibrine › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture d'organes › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CCR5 › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Effect of the CCL5-Releasing Fibrin Gel for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Effect of the CCL5-Releasing Fibrin Gel for...