Isoflurane anesthesia does not affect spinal cord neurovascular coupling: evidence from decerebrated rats.
Blood flow
Local field potential
Neurovascular coupling
Nociception
Pain
Spinal cord
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
15
01
2018
accepted:
22
03
2018
pubmed:
31
3
2018
medline:
30
5
2019
entrez:
31
3
2018
Statut:
ppublish
Résumé
Neurological examination remains the primary clinical investigation in patients with spinal cord injury. However, neuroimaging methods such as functional magnetic resonance imaging (fMRI) are promising tools for following functional changes in the course of injury, disease and rehabilitation. However, the relationship between neuronal activity and blood flow in the spinal cord on which fMRI relies has been largely overlooked. The objective of this study was to examine neurovascular coupling in the spinal cord of decerebrated rats during electrical stimulation of the sciatic nerve with and without isoflurane anesthesia (1.2%). Local field potentials (LFP) and spinal cord blood flow (SCBF) were recorded simultaneously in the lumbosacral enlargement. Isoflurane did not significantly alter LFP (p = 0.53) and SCBF (p = 0.57) amplitude. Accordingly, neurovascular coupling remained comparable with or without isoflurane anesthesia (p = 0.39). These results support the use of isoflurane in rodents to investigate nociceptive functions of the spinal cord using fMRI.
Identifiants
pubmed: 29600499
doi: 10.1007/s12576-018-0607-7
pii: 10.1007/s12576-018-0607-7
pmc: PMC10717246
doi:
Substances chimiques
Anesthetics, Inhalation
0
Isoflurane
CYS9AKD70P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-21Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 402176
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 05403
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