Cerebral serotonin transporter measurements with [


Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
02 2019
Historique:
pubmed: 14 4 2018
medline: 24 12 2019
entrez: 14 4 2018
Statut: ppublish

Résumé

Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [

Identifiants

pubmed: 29651896
doi: 10.1177/0271678X18770107
pmc: PMC6365604
doi:

Substances chimiques

Benzylamines 0
Carbon Radioisotopes 0
N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine 0
Radiopharmaceuticals 0
Serotonin Plasma Membrane Transport Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

210-222

Subventions

Organisme : Medical Research Council
ID : G1100809
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : R21 EB018964
Pays : United States

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Auteurs

Martin Nørgaard (M)

1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
2 Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Melanie Ganz (M)

1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
3 Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.

Claus Svarer (C)

1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Ling Feng (L)

1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Masanori Ichise (M)

4 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Rupert Lanzenberger (R)

5 Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Mark Lubberink (M)

6 Department of Nuclear Medicine and Positron Emission Tomography, Uppsala University, Uppsala, Sweden.

Ramin V Parsey (RV)

7 Department of Psychiatry, School of Medicine, Stony Brook University, Stony Brook, NY, USA.

Marios Politis (M)

8 Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.

Eugenii A Rabiner (EA)

9 Imanova Limited, London, UK.
10 Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Mark Slifstein (M)

7 Department of Psychiatry, School of Medicine, Stony Brook University, Stony Brook, NY, USA.

Vesna Sossi (V)

11 Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.

Tetsuya Suhara (T)

4 Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Peter S Talbot (PS)

12 Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Federico Turkheimer (F)

13 Department of Neuroimaging, King's College London, London, UK.

Stephen C Strother (SC)

14 Rotman Research Institute at Baycrest, University of Toronto, Toronto, Canada.

Gitte M Knudsen (GM)

1 Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
2 Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH