Structurally diverse diterpenoids from Trigonostemon howii.

Antineoplastic Agents, Phytogenic / chemistry Cell Line, Tumor Diterpenes / chemistry Euphorbiaceae / chemistry Humans Inhibitory Concentration 50 Molecular Structure Phytochemicals / analysis Plant Leaves / chemistry Plant Stems / chemistry
abietane diterpenoid cytotoxicities trigohowimine A

Journal

Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924

Informations de publication

Date de publication:
Apr 2019
Historique:
pubmed: 17 4 2018
medline: 17 7 2019
entrez: 17 4 2018
Statut: ppublish

Résumé

Phytochemical investigation on the stems and leaves of Trigonostemon howii resulted in the isolation of a new abietane diterpenoid, trigohowimine A (1), along with seven known structurally diverse diterpenoids (2-8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Compound 1 showed significant inhibitory effects against various human cancer cell lines with IC

Identifiants

DOI: 10.1080/14786419.2018.1462184 PMID: 29658332
pubmed: 29658332
doi: 10.1080/14786419.2018.1462184
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Diterpenes 0
Phytochemicals 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1169-1174

Auteurs

Yan-Ping Liu (YP)

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City , Hainan Normal University , Haikou , P. R. China.

Qing Wen (Q)

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City , Hainan Normal University , Haikou , P. R. China.
c College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.

Shi Hu (S)

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City , Hainan Normal University , Haikou , P. R. China.
c College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.

Yan-Lei Ma (YL)

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City , Hainan Normal University , Haikou , P. R. China.
c College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.

Zhi-Hua Jiang (ZH)

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City , Hainan Normal University , Haikou , P. R. China.
c College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.

Jin-Ying Tang (JY)

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City , Hainan Normal University , Haikou , P. R. China.
c College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.

Yan-Hui Fu (YH)

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Southern Medicinal Plants Resources of Haikou City , Hainan Normal University , Haikou , P. R. China.
c College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques d'origine végétale › Structurally diverse diterpenoids from...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Structurally diverse diterpenoids from...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Structurally diverse diterpenoids from...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Malpighiales › Euphorbiaceae › Structurally diverse diterpenoids from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structurally diverse diterpenoids from...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Structurally diverse diterpenoids from...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Structurally diverse diterpenoids from...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Structurally diverse diterpenoids from...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Structurally diverse diterpenoids from...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Tiges de plante › Structurally diverse diterpenoids from...