Activity-dependent modulation of hippocampal synaptic plasticity via PirB and endocannabinoids.
Animals
CA1 Region, Hippocampal
/ metabolism
Endocannabinoids
/ metabolism
Excitatory Postsynaptic Potentials
/ physiology
Hippocampus
/ metabolism
Long-Term Synaptic Depression
/ physiology
Male
Mice
Neuronal Plasticity
/ drug effects
Pyramidal Cells
/ metabolism
Receptors, Immunologic
/ metabolism
Signal Transduction
/ physiology
Synapses
/ metabolism
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
31
07
2017
accepted:
31
01
2018
revised:
21
01
2018
pubmed:
20
4
2018
medline:
10
3
2020
entrez:
20
4
2018
Statut:
ppublish
Résumé
The threshold for Hebbian synaptic plasticity in the CNS is modulated by prior synaptic activity. At adult CA3-CA1 synapses, endocannabinoids play a role in this process, but how activity engages and maintains this retrograde signaling system is not well understood. Here we show that conditional deletion of Paired Immunoglobulin-like receptor B (PirB) from pyramidal neurons in adult mouse hippocampus results in deficient LTD at CA3-CA1 synapses over a range of stimulation frequencies, accompanied by an increase in LTP. This finding can be fully explained by the disengagement of retrograde endocannabinoid signaling selectively at excitatory synapses. In the absence of PirB, the NMDAR-dependent regulation of endocannabinoid signaling is lost, while CB1R-dependent and group I mGluR-dependent regulation are intact. Moreover, mEPSC frequency in mutant CA1 pyramidal cells is elevated, consistent with a higher density of excitatory synapses and altered synapse pruning. Mice lacking PirB also perform better than WT in learning and memory tasks. These observations suggest that PirB is an integral part of an NMDA receptor-mediated synaptic mechanism that maintains bidirectional Hebbian plasticity and learning via activity-dependent endocannabinoid signaling.
Identifiants
pubmed: 29670176
doi: 10.1038/s41380-018-0034-4
pii: 10.1038/s41380-018-0034-4
pmc: PMC6372352
mid: NIHMS1010195
doi:
Substances chimiques
Endocannabinoids
0
Pirb protein, mouse
0
Receptors, Immunologic
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1206-1219Subventions
Organisme : NEI NIH HHS
ID : R01 EY002858
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071666
Pays : United States
Organisme : NEI NIH HHS
ID : R37 EY002858
Pays : United States
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