Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.
Adult
Autoantibodies
/ blood
Calcium-Binding Proteins
/ genetics
Croatia
Female
Humans
Iodide Peroxidase
/ immunology
Male
Membrane Proteins
/ genetics
Middle Aged
Polymorphism, Single Nucleotide
Receptors, N-Methyl-D-Aspartate
/ genetics
Sex Factors
Thyroglobulin
/ immunology
Thyroiditis, Autoimmune
/ genetics
Genome-wide association study
Meta-analysis
Single nucleotide polymorphism
Thyroglobulin
Thyroid antibody
Thyroid peroxidase
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
24
11
2017
revised:
28
02
2018
accepted:
16
04
2018
pubmed:
22
4
2018
medline:
31
12
2019
entrez:
22
4
2018
Statut:
ppublish
Résumé
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta-analysis of GWAS or bivariate results for all individuals. The bivariate analysis in females only revealed a genome-wide significant association for the locus near GRIN3A (rs4457391, P = 7.76 × 10
Identifiants
pubmed: 29678681
pii: S0888-7543(18)30242-8
doi: 10.1016/j.ygeno.2018.04.012
pii:
doi:
Substances chimiques
Autoantibodies
0
Calcium-Binding Proteins
0
DLK1 protein, human
0
GRIN3A protein, human
0
Membrane Proteins
0
Receptors, N-Methyl-D-Aspartate
0
Thyroglobulin
9010-34-8
Iodide Peroxidase
EC 1.11.1.8
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
737-743Subventions
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.